Products with Vasorelaxation bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6317 | Procyanidin C1 |
| Procyanidin C1 has anti-inflammatory effects, can inhibit IKKb activity in vitro and reduce the LPS-induced production of ROS, thus, it exerts the anti-inflammatory effects by inhibiting ERK1/2 and IKKb activity. Procyanidin C1 could be useful as a lead compound to develop inhibitors of cancer metastasis and other diseases related to epithelial-to-mesenchymal transition (EMT). Procyanidin C1 may represent a novel and potentially therapeutically relevant compound for the treatment of cardiovascular diseases, it -induced vasorelaxation is associated with the activation of the calcium-dependent NO/cGMP pathway, involving potassium channel activation. | |
| BCN6341 | Methyl hesperidin |
| Methyl hesperidin has potentiating effect on coronary vasodilation induced by adenosine or related compounds, It caused inhibition of nitrendipine transport in the ileum and jejunum, but not in the duodenum. Methyl hesperidin exerts no obvious toxic effects in mice of either sex when administered at a level as high as 5.0% in the diet. | |
| BCN6345 | 3-Butylidenephthalide |
| (Z)-3-butylidenephthalide has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-glucosidase (IC(50) 2.35 mM) in a noncompetitive fashion with a K(i) of 4.86 mM. It can induce a dose-dependent antinociceptive action in the hot-plate assay, it is also effective for controlling the pain provoked by chemical irritation at the doses of 10 and 31.6 mg/kg. | |
| BCN6351 | Senkyunolide A |
| Senkyunolide A is a useful standard compound for the quality evaluation and chemical differentiation between Rhizoma chuanxiong and Angelica sinensis, and suitable for the analysis of a large number of samples. Senkyunolide A has the vasorelaxation activity in contractions to various contractile agents in rat isolated aorta. | |
| BCN6415 | Fargesone B |
| 1.Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium influxes in a nonselective manner. | |
