Products with Vasorelaxation bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5526 | 8(14),15-Isopimaradien-3-ol |
| 1. ent-8(14),15-pimaradien-3beta-ol (8(14),15-Isopimaradien-3-ol) can induce vascular relaxation. 2. ent-8(14),15-pimaradien-3beta-ol displays high antibacterial activities (MIC values lower than 10 microg /mL for most pathogens). | |
| BCN5529 | Brazilin |
| Brazilin exhibits cancer preventive, anti-hepatotoxicity, antiplatelet activity, and anti-inflammatory activities, it also inhibits UVB-induced MMP-1/3 expressions and secretions by suppressing of NF-κB activation in human dermal fibroblasts, thus, it might be used as a potential agent for treatment of UV-induced skin photoaging. Brazilin has anti-IKK activity, can selectively disrupt proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components. Brazilin induces vasorelaxation by the increasing intracellular Ca(2+) concentration in endothelial cells of blood vessels and hence activating Ca(2+)/calmodulin-dependent NO synthesis. | |
| BCN5667 | Lochnerine |
| 1. Lochnerine shows potent vasorelaxant activity. 2. Lochnerine shows some antitumor activity, it can bring about complete inhibition of cell growth in P388 leukemia cells in vitro. | |
| BCN5668 | Vindorosine |
| 1. Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular smooth muscles. | |
| BCN5694 | Euxanthone |
| Euxanthone has vasorelaxation effect, may be through multiple pathways involved PKC-mediated signal pathway and calcium-independent pathway, it induces its vasodilator effect through inhibition of calcium-sensitive mechanisms activated by protein kinase C. Euxanthone-induced neurite outgrowth was actively regulated by transcription factor E2F-5 via PKC pathway, it-induced differentiation of the neuroblastoma BU-1 cells may be mediated through the differential expression of PKC-alpha, -beta, -delta, -lambda and -zeta isoforms. | |
