Products with Vasorelaxation bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1272 | Fraxinellone |
| Fraxinellone is a selective blocker of voltage-dependent Ca2+ channel, which possesses antimicrobial, anti-inflammatory, neuroprotective and vasorelaxing activities, Fraxinellone exhibits a variety of insecticidal activities including feeding-deterrent activity, inhibition of growth, and larvicidal activity. It inhibited the production of iNOS, COX-2, NF-kappa B, and PGE(2). | |
| BCN1390 | 3-Acetoxy-8(17),13E-labdadien-15-oic acid |
| ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the labdane involve the activation of the endothelial NO-cGMP pathway, the opening of K+ channels and the alteration on Ca2+ mobilization. | |
| BCN1419 | 3,3'',5-Triiodo-L-thyronine Sodium Salt |
| The administration of 3,3'',5-Triiodo-L-thyronine Sodium Salt (T3) elicited a vasodilatation in C57BL/6 mice even at the lowest concentration (10(-9)M), a maximal relaxation of more than 50% was observed with the concentrations between 10(-9) and 10(-8)M. | |
| BCN1743 | (2-Acetoxyethyl)trimethylammonium |
| 1. (2-Acetoxyethyl)trimethylammonium is a neurotransmitter, cholinergic and miotic agent. 2. (2-Acetoxyethyl)trimethylammonium is a cardiac depressant, and peripheral vasodilator. | |
| BCN1853 | Pramanicin |
| 1. Pramanicin, an antifungal agent, has vasorelaxant effect, it induces a slow endothelium-dependent relaxation, which could be reversed with the NO synthase inhibitor, L-NOARG . 2. Pramanicin has potent, selective, and irreversible inhibitory effect on the endothelial , thus it has potential development into an anti-angiogenic drug. 3. Pramanicin causes an initial slow endothelium-dependent, NO-mediated vascular relaxation, followed by a cytotoxic effect on vascular endothelial cells, eventually resulting in the loss of vasorelaxant function. 4. Pramanicin as a potential apoptosis-inducing small molecule, which acts through a well-defined JNK- and p38-dependent apoptosis signalling pathway in Jurkat T leukemia cells. 5. Pramanicin is an antimicrobial agent . | |
