3,3'',5-Triiodo-L-thyronine Sodium SaltPromotes adipogenic differentiation of MSCs; also thyroid hormone (T3) analog CAS# 55-06-1 |
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Quality Control & MSDS
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| Cas No. | 55-06-1 | SDF | Download SDF |
| PubChem ID | 23666110 | Appearance | Powder |
| Formula | C15H11I3NNaO4 | M.Wt | 672.96 |
| Type of Compound | Miscellaneous | Storage | Desiccate at -20°C |
| Synonyms | T3 Sodium salt; Sodium L-3,3',5-triiodothyronine; Liothyronine sodium | ||
| Solubility | DMSO : ≥ 42 mg/mL (62.41 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | sodium;(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate | ||
| SMILES | C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)[O-])N)I)I)O.[Na+] | ||
| Standard InChIKey | SBXXSUDPJJJJLC-YDALLXLXSA-M | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | The administration of 3,3'',5-Triiodo-L-thyronine Sodium Salt (T3) elicited a vasodilatation in C57BL/6 mice even at the lowest concentration (10(-9)M), a maximal relaxation of more than 50% was observed with the concentrations between 10(-9) and 10(-8)M. |
| Targets | Estrogen receptor | Antifection | Progestogen receptor |
| In vivo | Vascular function of the mesenteric artery isolated from thyroid hormone receptor-α knockout mice.[Pubmed: 25500991]J Vasc Res. 2014;51(5):350-9.This study evaluated the consequences of thyroid hormone receptor-α (TRα) disruption on vascular reactivity.
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3,3'',5-Triiodo-L-thyronine Sodium Salt Dilution Calculator
3,3'',5-Triiodo-L-thyronine Sodium Salt Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.486 mL | 7.4299 mL | 14.8597 mL | 29.7194 mL | 37.1493 mL |
| 5 mM | 0.2972 mL | 1.486 mL | 2.9719 mL | 5.9439 mL | 7.4299 mL |
| 10 mM | 0.1486 mL | 0.743 mL | 1.486 mL | 2.9719 mL | 3.7149 mL |
| 50 mM | 0.0297 mL | 0.1486 mL | 0.2972 mL | 0.5944 mL | 0.743 mL |
| 100 mM | 0.0149 mL | 0.0743 mL | 0.1486 mL | 0.2972 mL | 0.3715 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Liothyronine Sodium is the most potent form of thyroid hormone acting on the body to increase the basal metabolic rate, affect protein synthesis.
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Vascular function of the mesenteric artery isolated from thyroid hormone receptor-alpha knockout mice.[Pubmed:25500991]
J Vasc Res. 2014;51(5):350-9.
OBJECTIVE: This study evaluated the consequences of thyroid hormone receptor-alpha (TRalpha) disruption on vascular reactivity. METHODS: The activity of superior mesenteric arteries isolated from TRalpha knockout mice generated in the SV129 background (TRalpha(0/0)SV) or in a pure C57BL/6 background (TRalpha(0/0)C57) was compared to that of their corresponding wild-type strains (SV129 or C57BL/6 mice). RESULTS: The wild-type SV129 mice exhibited an impaired acetylcholine (Ach)-induced mesenteric artery relaxation compared to C57BL/6 mice, associated with greater responses to angiotensin II (AII) and phenylephrine (PE). The disruption of TRalpha decreased the vascular response to sodium nitroprusside and PE in both the SV129 and C57BL/6 genetic backgrounds. Responses to Ach and AII were also blunted, but only in TRalpha(0/0)C57 mice. The administration of 3,3'5-triiodo-L-thyronine sodium salt (T3) elicited a vasodilatation in C57BL/6 mice even at the lowest concentration (10(-9)M); a maximal relaxation of more than 50% was observed with the concentrations between 10(-9) and 10(-8)M. However, the response to T3 was nearly absent in TRalpha(0/0)C57 mice. CONCLUSION: TRalpha is essential for the control of vascular tone, particularly in thyroid hormone-mediated relaxation. The difference in response to Ach observed between the two wild-type mice should be taken into account for interpreting the vascular responses of genetically engineered mice.
