Hot Natural Products & Bioactive Compounds

1. Dehydroleucodine induces a TP73-dependent transcriptional regulation of multiple cell death target genes in human glioblastoma cells.
2. Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis.
3. Dehydroleucodine shows embryotoxicity.
4. Dehydroleucodine has gastric cytoprotective activity, it also inhibits the proliferation of vascular smooth muscle cells.
5. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating adipocyte differentiation by modulating the PPARγ expression, which is known to play a pivotal role during adipogenesis.
6. Dehydroleucodine has moderate anti-microbial activity against taphylococcus aureus and Staphylococcus epidermidis strains.
7. Dehydroleucodine has antidiarrheal activity.
8. Dehydroleucodine has anti-inflammatory activity, which may be attributed to interference with multiple targets on the level of transcription factors, such as NF-kappaB, and cytokines.

Hastatoside and verbenalin are major sleep-promoting components of V. officinalis. Hastatoside has anti-inflammatory activity.

1. Anatabine can suppress in a dose-dependent manner macrophage production of inducible nitric oxide synthase and cyclooxygenase 2, and ameliorate disease in a model of autoimmune thyroiditis.
2. Anatabine inhibits BACE-1 transcription and reduces BACE-1 protein levels in human neuronal like SHSY-5Y cells suggesting that the Aβ lowering properties of anatabine are mediated via a regulation of BACE-1 expression.
3. Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.

1-(4-Hydroxybenzoyl)glucose is a natural product from Luffa cylindrica (L.) Roem.

1. Globulol shows antimicrobial activity against Xanthomonas vesicatoria and Bacillus subtilis, the IC50 value of 158.0 microg/ mLand 737.2 microg/ mL, respectively.

1. Pyrolin has a strong antifungal activity and exerts a potent impact on the ultrastructure of M.fructicola.

1. Some carbazole derivatives show antibacterial and antifungal activities.

1. 5-Methoxyresorcinol is an antioxidant, it has aroxyl radical-scavenging action.