Hot Natural Products & Bioactive Compounds

1. Taxacin shows strong inhibitory effects on platelet aggregation induced by arachidonic acid (IC(50):21.9 microM).
2. Taxacin can suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a concentration-dependent manner.

Taxachitriene B is a natural product from the Chinese yew Taxus chinensis.

Taxachitriene A is a natural product from the Chinese yew Taxus chinensis.

1. Tauroursodeoxycholic acid (TUDCA) may enhance the secretory capacity of cholestatic hepatocytes by stimulation of exocytosis and insertion of transport proteins into apical membranes via PKC-dependent mechanisms.
2. TUDCA acts as a chemical chaperone to enhance protein folding and ameliorate ER stress, increases insulin sensitivity, it may be an effective pharmacological approach for treating insulin resistance.
3. TUDCA has wide-range neuroprotective effects, it may provide a potentially useful treatment in patients with hemorrhagic stroke and perhaps other acute brain injuries associated with cell death by apoptosis.
4. TUDCA is a strong modulator of AbetaE22Q-triggered apoptosis, it prevents E22Q Alzheimer's Abeta toxicity in human cerebral endothelial cells.
5. TUDCA exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver.

1. Rectal administration of taurocholic acid can stimulate glucagon-like peptide-1 and peptide YY by TGR5 receptor activation, which may have potential for the management of type 2 diabetes and obesity.
2. Taurocholic acid feeding prevents tumor necrosis factor-alpha-induced damage of cholangiocytes by a PI3K-mediated pathway.
3. Taurocholic acid feeding shows cytoprotective effects on the biliary tree after adrenergic denervation of the liver.
4. High concentraction of taurocholic acid can induce apoptosis in HTR-8/SVneo cells via overexpression of ERp29 and activation of p38.

Tasumatrol L is a natural product from Taxus sumatrana.

1. Taspine can inhibit growth and induce apoptosis of HUVEC in a dose-dependent manner.
2. Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo.
3. Taspine has shown meaningful angiogenesis activity .
4. Taspine exhibits a dose-related cicatrizant effect and an ED50 of 0.375 mg/kg.

1. Tabernanthine can decrease morphine and cocaine self-administration in rats, it may be effective in treating addiction to opioid and stimulant drugs.
2. Tabernanthine shows affinity for opiate receptors.
3. In vivo, both tabernanthine and carbolines cause a fine general tremor, suggesting that a possible interaction with benzodiazepine receptors could be involved in the activity of tabernanthine.
4. Tabernanthine tartrate has peripheral cardiovascular effects in anaesthetized rats.