Hot Natural Products & Bioactive Compounds

1. Rutamarin exhibits remarkable cytotoxic activity against HT29 cells (IC50 value of 5.6 uM), it has the potential to be developed as an anticancer agent.
2. (+)-Rutamarin is effective in inhibiting EBV DNA replication and virion production but shows little adverse effect on cell proliferation.
3. (+)-Rutamarin is a dual inducer of both GLUT4 translocation and expression efficiently ameliorates glucose homeostasis in insulin-resistant mice.

1. 8-Hydroxy-ar-turmerone may exhibit antitumor activity against breast cancer cells via cell death and cell cycle arrest.

1. 4-Methoxycinnamyl alcohol shows toxicity against MCF-7, HeLa and DU145 cancer cell line.

1. ar-Turmerone could be used as a low cost botanical insecticide for integrated management of cabbage looper in vegetable production.
2. ar-Turmerone may have notable antibacterial activity to Bacillus cereus and Staphylococcus aureus, antifungal activity to Aspergillus niger, and cytotoxic activity to Hs 578T (breast tumor) and PC-3 (prostate tumor) cells.
3. ar-Turmerone shows larvicidal and biting deterrent activity against Aedes aegypti and Anopheles quadrimaculatus (Culicidae: Diptera).
4. ar-Turmerone exerts potent anti-inflammatory effects via suppression of the inflammatory cytokines IFN-γ and IL-2.
5. ar-Turmerone induces neural stem cells (NSCs) proliferation, hence it constitutes a promising candidate to support regeneration in neurologic disease.
6. ar-Turmerone displays anticonvulsant properties in both acute seizure models in mice and modulates the expression patterns of two seizure-related genes (c-fos and brain-derived neurotrophic factor [bdnf]) in zebrafish.
7. ar-Turmerone has a cytotoxic effect on L-1210 and HL-60 cells, it also has a repressive effect on P388D1 lymphocytic leukemia.

1. Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 uM.
2. Gentisin has mutagenic activity.

1,2,3,7-Tetramethoxyxanthone is a natural product from Polygala tenuifolia Willd.

1. Anhydrosecoisolariciresinol can significantly decrease the growth of human breast cancer MCF-7 and MDA-MB-231 cell lines at 50 and 100 microM.

1. 1,7-Dihydroxy-2,3-dimethoxyxanthone shows significant inhibitory effects on LPS-induced NO production in BV2 microglia cells.
2. 1,7-Dihydroxy-2,3-dimethoxyxanthone antagonises in a non competitive but, reversible manner the contractions induced by chemical inflammatory mediators in the guinea pig trachea in vitro, thus, it may have medicinal use in the management of inflammation, asthma and allergy.