Hot Natural Products & Bioactive Compounds

1. Gossypin exerts potent radical scavenging activity generated from 1,1-diphenyl-2-picrylhydrazyl.
2. Gossypin exerts neuroprotective effects in the cultured cortical cells by inhibiting oxidative stress- and Abeta-induced toxicity, and that the antioxidant properties of gossypin may contribute to its neuroprotective actions.
3. Gossypin inhibits the NF-kappaB activation pathway, which may explain its role in the suppression of inflammation, carcinogenesis, and angiogenesis.
4. Gossypin has anticonvulsant activity.
5. Gossypin is a new hypocholesterolemic agent that up-regulates LDLR expression independent of SREBP-2 but is dependent on ERK activation.
6. Gossypin has antiinflammatory and antinociceptive activities.
7. Gossypin has anti-allergic activity, it i can nhibit mast cell-derived allergic reactions.
8. Gossypin has antidiabetic activity in streptozotocin-induced experimental diabetes in rats.
9. Gossypin has cytotoxic and antibacterial activities.
10. Gossypin has ameliorative effect against gentamicin-induced nephrotoxicity in rats.
11. Gossypin shows inhibitory effects on RANKL-induced osteoclast differentiation and bone resorption in murine macrophages (LB364).

1. Baptifoline has cytotoxic activity.

1. Caulophine has the ability to protect cardiomyocytes from oxidative and ischemic injury through an antioxidative mechanism.

1. Uralenol significantly shows the inhibitory activities against the PTP1B enzyme.
2. Uralenol shows inhibitory activities on mushroom tyrosinase using l-tyrosine as substrate（IC50 =49.5 uM).
3. Uralenol shows potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro.

1. Broussonol E may show cytotoxic activity against several different cell lines.

1. Methylphophorbide A shows antioxidative and anticarcinogenic activities.

1. Bruceine C shows in vitro antitrypanosomal activities against trypomastigotes of T. evansi .

Bruceantinol A is a natural product from Brucea javanica.