Baptifoline

CAS# 732-50-3

Baptifoline

Catalog No. BCN7988----Order now to get a substantial discount!

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Quality Control of Baptifoline

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Chemical structure

Baptifoline

3D structure

Chemical Properties of Baptifoline

Cas No. 732-50-3 SDF Download SDF
PubChem ID 160543 Appearance Powder
Formula C15H20N2O2 M.Wt 260.33
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (1R,9R,10R,12S)-12-hydroxy-7,15-diazatetracyclo[7.7.1.02,7.010,15]heptadeca-2,4-dien-6-one
SMILES C1CN2CC3CC(C2CC1O)CN4C3=CC=CC4=O
Standard InChIKey AOOCSKCGZYCEJX-NRWUCQMLSA-N
Standard InChI InChI=1S/C15H20N2O2/c18-12-4-5-16-8-10-6-11(14(16)7-12)9-17-13(10)2-1-3-15(17)19/h1-3,10-12,14,18H,4-9H2/t10-,11-,12+,14-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Baptifoline

The herbs of Sophora chrysophylla

Biological Activity of Baptifoline

Description1. Baptifoline has cytotoxic activity.

Baptifoline Dilution Calculator

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Baptifoline Molarity Calculator

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Preparing Stock Solutions of Baptifoline

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.8413 mL 19.2064 mL 38.4128 mL 76.8256 mL 96.032 mL
5 mM 0.7683 mL 3.8413 mL 7.6826 mL 15.3651 mL 19.2064 mL
10 mM 0.3841 mL 1.9206 mL 3.8413 mL 7.6826 mL 9.6032 mL
50 mM 0.0768 mL 0.3841 mL 0.7683 mL 1.5365 mL 1.9206 mL
100 mM 0.0384 mL 0.1921 mL 0.3841 mL 0.7683 mL 0.9603 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Baptifoline

Quinolizidine Alkaloids from Sophora alopecuroides.[Pubmed:28054778]

J Nat Prod. 2000 Feb;63(2):190-192.

A new matrine-type alkaloid, 7alpha-hydroxysophoramine (1), was isolated from the aerial parts of Sophora alopecuroides together with eight known alkaloids, 12beta-hydroxysophocarpine (2), sophoramine (3), 14beta-hydroxymatrine, matrine, sophoridine, sophocarpine, adenocarpine, and Baptifoline. The structures of compounds 1-3 were confirmed through single-crystal X-ray diffraction analysis.

Cytotoxic constituents from Anagyris foetida leaves.[Pubmed:16887297]

Fitoterapia. 2006 Dec;77(7-8):595-7.

Anagyris foetida extracts were investigated in preliminary cytotoxic tests against two tumour cell lines. Chromatographic separations on active extracts led to the isolation of two alkaloids, anagyrine (1) and Baptifoline (2), as well of isorhamnetin (3) and syringin 4-O-beta-D-glucopyranoside (4). In vitro cytotoxicity of compounds 1-3 was also evaluated.

Chemotaxonomy of Portuguese Ulex: quinolizidine alkaloids as taxonomical markers.[Pubmed:16876210]

Phytochemistry. 2006 Sep;67(17):1943-9.

Six species of Portuguese Ulex L. in a total of nineteen populations were studied by GC-EIMS as to their content in quinolizidine alkaloids. Sparteine, beta-isosparteine, jussiaeiine A, N-methylcytisine, cytisine, 5,6-dehydrolupanine, rhombifoline, lupanine, jussiaeiine B, N-formylcytisine, N-acetylcytisine, anagyrine, jussiaeiine C, jussiaeiine D, pohakuline, Baptifoline, and epiBaptifoline were detected. Analysis of the chromatograms showed that the chemical profile of all species was mainly composed of N-methylcytisine, cytisine, anagyrine, and jussiaeiines A, B, C and D. Therefore a quantification study of these alkaloids in all the populations studied was done by GC. These data were then submitted to cluster analysis and principal component analysis, which allowed the definition of five chemotypes and the recognition of hybrids. N-methylcytisine, cytisine, and jussiaeiines A, C and D are recognized as markers of this genus in Portugal.

Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture.[Pubmed:10543898]

J Nat Prod. 1999 Oct;62(10):1385-9.

The novel alkaloid thalictroidine (1), as well as the known alkaloids taspine (2), magnoflorine (3), anagyrine (4), Baptifoline (5), 5,6-dehydro-alpha-isolupanine (6), alpha-isolupanine (7), lupanine (8), N-methylcytisine (9), and sparteine (10), were identified from an extract of Caulophyllum thalictroides rhizomes. N-Methylcytisine exhibited teratogenic activity in the rat embryo culture (REC), an in vitro method to detect potential teratogens. The structure of 1 was elucidated using various spectroscopic methods, primarily by NMR techniques. Thalictroidine, anagyrine, and alpha-isolupanine were not teratogenic in the REC at tested concentrations. Taspine (2) showed high embryotoxicity, but no teratogenic activity, in the REC.

Quinolizidine alkaloids from Sophora alopecuroides.[Pubmed:10691706]

J Nat Prod. 2000 Feb;63(2):190-2.

A new matrine-type alkaloid, 7alpha-hydroxysophoramine (1), was isolated from the aerial parts of Sophora alopecuroides together with eight known alkaloids, 12beta-hydroxysophocarpine (2), sophoramine (3), 14beta-hydroxymatrine, matrine, sophoridine, sophocarpine, adenocarpine, and Baptifoline. The structures of compounds 1-3 were confirmed through single-crystal X-ray diffraction analysis.

Primary constituents of blue cohosh: quantification in dietary supplements and potential for toxicity.[Pubmed:23420136]

Anal Bioanal Chem. 2013 May;405(13):4409-17.

Dietary supplements containing dried roots or extracts of the roots and/or rhizomes of blue cohosh (Caulophyllum thalictroides) are widely available. This botanical has a long history of use by Native Americans and its use continues to the present day. The primary constituents of blue cohosh are its alkaloids and saponins. The structures of the alkaloids magnoflorine, Baptifoline, anagyrine, and N-methylcytisine have been known for many years. The last 10 years have seen a great increase in isolation and identification of the large number of saponins present in blue cohosh. Important developments in nuclear magnetic resonance techniques have contributed substantially to the increase in elucidation of the structures of the complex saponins. Several authors have described quantitative methods for both the alkaloids and saponins in blue cohosh. Such methods have made it possible to quantify these constituents in dietary supplements containing this botanical ingredient. Concentrations of both alkaloids and saponins vary substantially in dietary supplements of blue cohosh. The nicotinic alkaloid, N-methylcytisine, a potent toxicant, has been found in all dietary supplements of blue cohosh analyzed. The teratogenic alkaloid anagyrine has been found in some but not all dietary supplements.

Quinolizidine alkaloids from the curare adjuvant Clathrotropis glaucophylla.[Pubmed:12453529]

Phytochemistry. 2002 Dec;61(8):975-8.

The bark of Clathrotropis glaucophylla (Fabaceae) is used as admixture of curare arrow poison by the Yanomami; Amerindians in Venezuela. A new quinolizidine alkaloid (QA), (-)-13alpha-hydroxy-15alpha-(1-hydroxyethyl)-anagyrine [(-)-clathrotropine], was isolated from the alkaloid extract of C. glaucophylla bark, together with eleven known QAs: (-)-anagyrine, (-)-thermopsine, (-)-Baptifoline, (-)-epiBaptifoline, (-)-rhombifoline, (-)-tinctorine, (-)-cytisine, (-)-N-methylcytisine, (-)-lupanine, (-)-6alpha-hydroxylupanine and (+)-5,6-dehydrolupanine. The isolation and structure elucidation were performed with the aid of chromatographic (TLC, HPLC and CC) and spectroscopic (UV and 1D/2D NMR) methods, and mass spectrometry. To our knowledge, this is the first time quinolizidine alkaloids have been isolated from an arrow poison ingredient. It is also the first report on Clathrotropis species being used for preparation of arrow poison.

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