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1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid

CAS# 73281-83-1

1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid

Catalog No. BCN1369----Order now to get a substantial discount!

Product Name & Size Price Stock
1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid: 5mg $886 In Stock
1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid: 10mg Please Inquire In Stock
1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid: 20mg Please Inquire Please Inquire
1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid: 50mg Please Inquire Please Inquire
1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid: 100mg Please Inquire Please Inquire
1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid: 200mg Please Inquire Please Inquire
1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid: 500mg Please Inquire Please Inquire
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Quality Control of 1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid

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Chemical structure

1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid

3D structure

Chemical Properties of 1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid

Cas No. 73281-83-1 SDF Download SDF
PubChem ID 12554170 Appearance Powder
Formula C12H11NO3 M.Wt 217.2
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1,2-dimethyl-4-oxoquinoline-3-carboxylic acid
SMILES CC1=C(C(=O)C2=CC=CC=C2N1C)C(=O)O
Standard InChIKey RDEXTEPFIVECBD-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid

The herbs of Micromelum sp.

1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid Dilution Calculator

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1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid Molarity Calculator

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Preparing Stock Solutions of 1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.6041 mL 23.0203 mL 46.0405 mL 92.081 mL 115.1013 mL
5 mM 0.9208 mL 4.6041 mL 9.2081 mL 18.4162 mL 23.0203 mL
10 mM 0.4604 mL 2.302 mL 4.6041 mL 9.2081 mL 11.5101 mL
50 mM 0.0921 mL 0.4604 mL 0.9208 mL 1.8416 mL 2.302 mL
100 mM 0.046 mL 0.2302 mL 0.4604 mL 0.9208 mL 1.151 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 1,4-Dihydro-1,2-dimethyl-4-oxo-3-quinolinecarboxylic acid

Synthesis, biological activities and SAR studies of novel 1-Ethyl-7-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid based diacyl and sulfonyl acyl hydrazines.[Pubmed:24038900]

Pest Manag Sci. 2014 Jul;70(7):1071-82.

BACKGROUND: Diacyl hydrazines have attracted significant interest in medicine, pesticide chemistry and material science. It is an important class of insect growth regulators. In this study, acyl hydrazine, the essential active group was incorporated in to nalidixic acid with the aim of combining the active groups to generate more potent agrochemical. RESULTS: Various nalidixic acid based diacyl and sulphonyl acyl hydrazines derivatives were synthesized and characterized by spectral techniques. These compounds were screened for the antifungal activity against five pathogenic fungi, nitrification inhibitory activity and insect growth regulator (IGR) activity against Spodoptera litura. The fungicidal activity was screened against R. bataticola, S. rolfsii, R. solani, F. oxysporum and A. porri. Most of the compounds showed moderate to good antifungal activity against A. porri (ED50 = 29.6-495.9 microg/mL). All the compounds showed significant nitrification inhibitory activity at 5% level. IGR activity was examined by feeding method against S. litura. CONCLUSION: The study revealed that a few compounds possessed good activity against three different pests namely certain fungus, soil bacteria and insect, among which, compound 37 (R' = 4-chlorophenyl) behaved the best.

6,7-Difluoro-1,4-dihydro-1-methyl-4-oxo-3-quinolinecarboxylic acid, a newly designed fluorescence enhancement-type derivatizing reagent for amino compounds.[Pubmed:20108029]

J Fluoresc. 2010 Mar;20(2):615-24.

A novel fluorescence enhancement-type derivatizing reagent for amino compounds, 6,7-difluoro-1,4-dihydro-1-methyl-4-oxo-3-quinolinecarboxylic acid (FMQC), was developed. FMQC reacts with aliphatic primary amino compounds to afford strong fluorescent derivatives having high photo-and thermo-stabilities. The FMQC derivatives of amino compounds showed 12-159 times higher fluorescence quantum efficiencies than those of FMQC in aqueous and polar organic media. Additionally, the absorption and fluorescence emission wavelength of the derivatives are red-shifted from those of FMQC. These differences in the fluorescence properties between FMQC and the fluorescent derivative enabled the simple and highly sensitive determination of amino compounds without removing any excess unreacted FMQC by using a simple spectrofluorometer as well as HPLC.

Novel fluoroquinolone antibacterial agents containing oxime-substituted (aminomethyl)pyrrolidines: synthesis and antibacterial activity of 7-(4-(aminomethyl)-3-(methoxyimino)pyrrolidin-1-yl)-1-cyclopropyl-6- fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid (LB20304).[Pubmed:9357525]

J Med Chem. 1997 Oct 24;40(22):3584-93.

New pyrrolidine derivatives, which bear an alkyloxime substituent in the 4-position and an aminomethyl substituent in the 3-position of the pyrrolidine ring, have been synthesized and coupled with various quinolinecarboxylic acids to produce a series of new fluoroquinolone antibacterials. These fluoroquinolones were found to possess potent antimicrobial activity against both Gram-negative and Gram-positive organisms, including methicillin resistant Staphylococcus aureus (MRSA). Variations at the C-8 position of the quinolone nucleus included fluorine, chlorine, nitrogen, methoxy, and hydrogen atom substitution. The activity imparted to the substituted quinolone nucleus by the C-8 substituent was in the order F (C5-NH2) > F (C5-H) > naphthyridine > Cl = OMe = H against Gram-positive organisms. In the case of Gram-negative strains, activity was in the order F (C5-NH2) > naphthyridine = F (C5-H) > H > Cl > OMe. The advantages provided by the newly introduced oxime group of the quinolones were clearly demonstrated by their comparison to a desoximino compound 30. In addition, the oxime moiety greatly improved the pharmacokinetic parameters of the novel quinolones. Among these compounds, compound 20 (LB20304) showed the best in vivo efficacy and pharmacokinetic profile in animals, as well as good physical properties. The MICs (microgram/mL) of LB20304, compound 30, and ciprofloxacin against several test organisms are as follows: S. aureus 6538p (0.008, 0.031, and 0.13), methicillin resistant S. aureus 241 (4, 16, and 128), Streptococcus epidermidis 887E (0.008, 0.016, and 0.13), methicillin resistant S. epidermidis 178 (4, 32, and 128), Enterococcus faecalis 29212 (0.063, 0.13, and 1), Pseudomonas aeruginosa 1912E (0.25, 0.5, and 0.13), Escherichia coli 3190Y (0.008, 0.016, and 0.008), Enterobacter cloacae P99 (0.008, 0.031, and 0.008), Actinobacter calcoaceticus 15473 (0.063, 0.13, and 0.25). On the basis of these promising results, LB20304 was selected as a candidate for further evaluation.

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