Niclosamide monohydrateCAS# 73360-56-2 |
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Quality Control & MSDS
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Chemical structure
3D structure
Cas No. | 73360-56-2 | SDF | Download SDF |
PubChem ID | 12296604 | Appearance | Powder |
Formula | C13H10Cl2N2O5 | M.Wt | 345.13 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Synonyms | BAY2353 monohydrate | ||
Solubility | Soluble in DMSO | ||
Chemical Name | 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide;hydrate | ||
SMILES | C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O.O | ||
Standard InChIKey | ZBXRPLQCPHTHLM-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C13H8Cl2N2O4.H2O/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15;/h1-6,18H,(H,16,19);1H2 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Niclosamide monohydrate is an inhibitor of STAT with IC50 of 0.7 μM and inhibits DNA replication in a cell-free assay.In Vitro:Niclosamide (<5 μM) inhibits STAT3-mediated luciferase reporter activity with IC50 of 0.25 μM in a dose dependent manner in HeLa cells. Niclosamide (<2 μM) dose dependently inhibits the phosphorylation of STAT3 in Du145 cells. Niclosamide (1 μM) inhibits the EGF-induced nuclear translocation of STAT3 in Du145 cells. Niclosamide (<2 μM) dose dependently inhibits the transcription of STAT3 downstream genes in Du145 cells. Niclosamide (<10 μM) dose dependently induces G0/G1 arrest and apoptosis of Du145 cancer cells[1]. Niclosamide is able to inhibit SARS-CoV replication at a micromolar concentration in Vero E6 cells infected with SARS-CoV[2]. Niclosamide (<7.5 μM) promotes Frizzled1 endocytosis, downregulates Dishevelled-2 protein, and inhibits Wnt3A-stimulated beta-catenin stabilization and LEF/TCF reporter activity in U2OS cells[3]. Niclosamide inhibits the TNF-induced NF-κB reporter activity in a dose- and time-dependent manner in U2OS cells. Niclosamide (125 nM) inhibits NF-κB activation induced by p65, IKKα, IKKβ, IKKγ, and TAK1 in U2OS cells. Niclosamide (<500 nM) completely block the time- and dose-dependent TNFα-induced alteration of the NF-κB-DNA complex in HL-60 cells. Niclosamide (<10 nM) inhibits constitutive NF-κB activation in U266 cells. Niclosamide inhibits TNF-induced degradation of IκBα and relocation of p65 in a dose- and time-dependent manner in HL-60, Molm13, or AML primary cells. Niclosamide (500 nM) decreases TNF-induced NF-κB-dependent gene products involved in cell survival in HL-60 cells. Niclosamide dose dependently inhibits the growth and induces robust apoptosis of AML cells associated with decreased Mcl-1 and XIAP levels and increased intracellular ROS levels[4].In Vivo:Niclosamide (40 mg/kg/d, i.p.) inhibits growth of xenografted AML cells in nude mice bearing HL-60 xenograft tumors[4]. References: |
Niclosamide monohydrate Dilution Calculator
Niclosamide monohydrate Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.8975 mL | 14.4873 mL | 28.9746 mL | 57.9492 mL | 72.4365 mL |
5 mM | 0.5795 mL | 2.8975 mL | 5.7949 mL | 11.5898 mL | 14.4873 mL |
10 mM | 0.2897 mL | 1.4487 mL | 2.8975 mL | 5.7949 mL | 7.2436 mL |
50 mM | 0.0579 mL | 0.2897 mL | 0.5795 mL | 1.159 mL | 1.4487 mL |
100 mM | 0.029 mL | 0.1449 mL | 0.2897 mL | 0.5795 mL | 0.7244 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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Niclosamide Monohydrate(BAY2353 monohydrate) is used for the treatment of most tapeworm infections by inhibit DNA replication.
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Expanding the structural landscape of niclosamide: a high Z' polymorph, two new solvates and monohydrate H(A).[Pubmed:25940896]
Acta Crystallogr C Struct Chem. 2015 May;71(Pt 5):394-401.
Three new crystalline phases are reported for the drug niclosamide [5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide], C13H8Cl2N2O4. A new high-Z' polymorph (denoted Form II) is described, with four molecules in the asymmetric unit in the space group P2/n. The structure exhibits pseudosymmetry, including local translations and screw-type operations. The niclosamide molecules are linked by O-H...O hydrogen bonds into chains, and the chains are packed so that the molecules form face-to-face (stacking) and end-to-end interactions within layers perpendicular to the chains. There are two different layer arrangements, giving a structure that is relatively complex. In the acetone and acetonitrile solvates, the incorporated solvent molecules accept hydrogen bonds from the OH groups of niclosamide, and the niclosamide molecules are stacked in a face-to-face manner. In the acetone solvate, C13H8Cl2N2O4.C3H6O, V-shaped arrangements are formed in which the nitrobenzene ends of the niclosamide molecules are brought into face-to-face contact. In the acetonitrile solvate, C13H8Cl2N2O4.CH3CN, stacking occurs by translation along a short axis (ca 3.8 A) and the crystals are frequently observed to be twinned by twofold rotation around that axis. The acetonitrile molecules occupy channels in the structure. A complete structure is provided for Niclosamide monohydrate, C13H8Cl2N2O4.H2O, polymorph HA, obtained by Rietveld refinement against laboratory powder X-ray diffraction data. It has been suggested that this compound is related to the methanol solvate of niclosamide [Harriss, Wilson & Radosevljevic Evans (2014). Acta Cryst. C70, 758-763], but it is found that the two are not fully isostructural: they contain isostructural two-dimensional layers, but the layers are arranged differently in the two structures. This suggests that HA may have the potential for polytypism, and features in the Rietveld difference curve indicate that a polytype fully isostructural with the methanol solvate might be present.