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Methylnissolin

CAS# 733-40-4

Methylnissolin

Catalog No. BCN1368----Order now to get a substantial discount!

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Chemical structure

Methylnissolin

3D structure

Chemical Properties of Methylnissolin

Cas No. 733-40-4 SDF Download SDF
PubChem ID 5319733 Appearance Powder
Formula C17H16O5 M.Wt 300.3
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 9,10-dimethoxy-6a,11a-dihydro-6H-[1]benzofuro[3,2-c]chromen-3-ol
SMILES COC1=C(C2=C(C=C1)C3COC4=C(C3O2)C=CC(=C4)O)OC
Standard InChIKey UOVGCLXUTLXAEC-UHFFFAOYSA-N
Standard InChI InChI=1S/C17H16O5/c1-19-13-6-5-10-12-8-21-14-7-9(18)3-4-11(14)15(12)22-16(10)17(13)20-2/h3-7,12,15,18H,8H2,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Methylnissolin

The herbs of Astragalus sinicus L.

Biological Activity of Methylnissolin

DescriptionMethylnissolin is a natural product from A. membranaceus.
TargetsTNF-α | IL Receptor
In vitro

Flavonoids from Astragalus membranaceus and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells.[Pubmed: 23771500 ]

Arch Pharm Res. 2014 Feb;37(2):186-92.

Radix Astragali (Astragalus membranaceus) is an important traditional Chinese medicine that is widely used as a tonic to enhance the body's natural defense mechanisms.
METHODS AND RESULTS:
In this phytochemical study, 12 flavonoids, isoliquiritigenin (1), liquiritigenin (2), calycosin (3), calycosin 7-O-β-D-glucoside (4), formononetin (5), formononetin 7-O-β-D-glucoside (6), daidzein (7), daidzein 7-O-β-D-glucoside (8), Methylnissolin (9), Methylnissolin 3-O-β-D-glucoside (10), isomucronulatol (11), and isomucronulatol 7-O-β-D-glucoside (12), were isolated from the roots of A. membranaceus. Their structures were elucidated by comparing spectroscopic data with reported values. The effects of the isolated compounds on lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells were investigated. Compounds 1 and 2 exhibited significant inhibitory effects on LPS-induced IL-6 and IL-12 p40 production, with IC50 values ranging from 2.7 to 6.1 μM. Compound 1 also showed a moderate inhibitory effect on LPS-stimulated production of TNF-α with an IC50 value of 20.1 μM.
CONCLUSIONS:
Further studies of the potential anti-inflammatory effects and benefits of flavonoids from A. membranaceus are warranted.

Methylnissolin Dilution Calculator

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Methylnissolin Molarity Calculator

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Preparing Stock Solutions of Methylnissolin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.33 mL 16.65 mL 33.3 mL 66.6001 mL 83.2501 mL
5 mM 0.666 mL 3.33 mL 6.66 mL 13.32 mL 16.65 mL
10 mM 0.333 mL 1.665 mL 3.33 mL 6.66 mL 8.325 mL
50 mM 0.0666 mL 0.333 mL 0.666 mL 1.332 mL 1.665 mL
100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.666 mL 0.8325 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Methylnissolin

Flavonoids from Astragalus membranaceus and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells.[Pubmed:23771500]

Arch Pharm Res. 2014 Feb;37(2):186-92.

Radix Astragali (Astragalus membranaceus) is an important traditional Chinese medicine that is widely used as a tonic to enhance the body's natural defense mechanisms. In this phytochemical study, 12 flavonoids, isoliquiritigenin (1), liquiritigenin (2), calycosin (3), calycosin 7-O-beta-D-glucoside (4), formononetin (5), formononetin 7-O-beta-D-glucoside (6), daidzein (7), daidzein 7-O-beta-D-glucoside (8), Methylnissolin (9), Methylnissolin 3-O-beta-D-glucoside (10), isomucronulatol (11), and isomucronulatol 7-O-beta-D-glucoside (12), were isolated from the roots of A. membranaceus. Their structures were elucidated by comparing spectroscopic data with reported values. The effects of the isolated compounds on lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells were investigated. Compounds 1 and 2 exhibited significant inhibitory effects on LPS-induced IL-6 and IL-12 p40 production, with IC50 values ranging from 2.7 to 6.1 muM. Compound 1 also showed a moderate inhibitory effect on LPS-stimulated production of TNF-alpha with an IC50 value of 20.1 muM. Further studies of the potential anti-inflammatory effects and benefits of flavonoids from A. membranaceus are warranted.

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