UralenolCAS# 139163-15-8 |
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| Cas No. | 139163-15-8 | SDF | Download SDF |
| PubChem ID | 5315126 | Appearance | Powder |
| Formula | C20H18O7 | M.Wt | 370.35 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 2-[3,4-dihydroxy-5-(3-methylbut-2-enyl)phenyl]-3,5,7-trihydroxychromen-4-one | ||
| SMILES | CC(=CCC1=C(C(=CC(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O)C | ||
| Standard InChIKey | WOMWVGHYSNATOB-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C20H18O7/c1-9(2)3-4-10-5-11(6-14(23)17(10)24)20-19(26)18(25)16-13(22)7-12(21)8-15(16)27-20/h3,5-8,21-24,26H,4H2,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Glycyrrhiza uralensis
| Description | 1. Uralenol significantly shows the inhibitory activities against the PTP1B enzyme. 2. Uralenol shows inhibitory activities on mushroom tyrosinase using l-tyrosine as substrate（IC50 =49.5 uM). 3. Uralenol shows potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro. |
| Targets | Tyrosinase | Estrogen receptor | Progestogen receptor |
Uralenol Dilution Calculator
Uralenol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.7001 mL | 13.5007 mL | 27.0015 mL | 54.003 mL | 67.5037 mL |
| 5 mM | 0.54 mL | 2.7001 mL | 5.4003 mL | 10.8006 mL | 13.5007 mL |
| 10 mM | 0.27 mL | 1.3501 mL | 2.7001 mL | 5.4003 mL | 6.7504 mL |
| 50 mM | 0.054 mL | 0.27 mL | 0.54 mL | 1.0801 mL | 1.3501 mL |
| 100 mM | 0.027 mL | 0.135 mL | 0.27 mL | 0.54 mL | 0.675 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Natural PTP1B inhibitors from Broussonetia papyrifera.[Pubmed:12419367]
Bioorg Med Chem Lett. 2002 Dec 2;12(23):3387-90.
Two new compounds, 8-(1,1-dimethylallyl)-5'-(3-methylbut-2-enyl)-3',4',5,7-tetrahydroxyflanvonol (1), 3'-(3-methylbut-2-enyl)-3',4',7-trihydroxyflavane (2) and three known compounds 3,3',4',5,7-pentahydroxyflavone (3), Uralenol (4), broussochalcone A (5) were isolated from the roots of Broussonetia papyrifera, and their structures determined by spectroscopic methods. Compounds 1, 3, 4 and 5 significantly show the inhibitory activities against the PTP1B enzyme.
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