Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 4481 - 4488 of 9359 hot products
| Catalog No. | Product Name |
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| BCN2395 | Sclareol |
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Sclareol possesses anti-cancer, anti-osteoarthritic, immune-regulation and anti-inflammatory activities, it inhibits the MMPs, iNOS and COX-2 expression on mRNA and protein levels, while increases the TIMP-1 expression, and over-production of NO and PGE2 is also suppressed by Sclareol ameliorated cartilage degradation. Sclareol induces plant resistance to root-knot nematode partially through ethylene-dependent enhancement of lignin accumulation.
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| BCN2396 | Genistin |
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Supplementation of Genistin alone or with selenium provides antioxidant defense with high-potential chemopreventive activity against DMBA-induced mammary tumors more than selenium alone.Intravitreal injection of Genistin is safe and effective in reducing traumatic PVR in clinical treatment.
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| BCN2397 | Doxycycline |
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1. Doxycycline inhibits B cell, MC and histamine function and attenuates experimental allergic conjunctivitis and systemic anaphylaxis by possible modulating the PI3K/Akt pathway.
2. Doxycycline, an inhibitor of matrix metalloproteinases, has beneficial effects on sulfur mustard-induced ocular pathologies depend on the injury stage. 3. Doxycycline treatment of microfilaremic dogs gradually reduces numbers of microfilariae and blocks further transmission of heartworms, also has a slow-kill effect on adult heartworms. |
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| BCN2398 | Albaspidin AP |
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1. Albaspidin-AP, -PP, -PB inhibit Fatty acid synthase (FAS) with IC50 values ranging from 23.1+/-1.4 to 71.7+/-3.9 microM, they could be considered to be a promising class of FAS inhibitors, and FAS is emerging as a potential therapeutic target to treat cancer and obesity.
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| BCN2399 | Nigranoic acid |
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1. Nigranoic acid shows activity in several anti-HIV reverse transcriptase and polymerase assays.
2. Nigranoic acid is able to promote NO production and stimulate phosphorylation of ERK1/2 through Ca(2+) influx, further impact expression of BDNF and c-fos, may be benefit to enhance mental and intellectual functions. 3. Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation. 4. Nigranoic acid exhibits significant inhibitory activity against HNE with the IC50 value of 3.77 μM, and six esters displayed considerable inhibitory effects on HNE with IC50 values in the range of 2.61-8.95 μM. |
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| BCN2400 | Berbamine hydrochloride |
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Berbamine hydrochloride and Ver block the calcium-induced contraction of depolarized pig coronary artery strips, indicate that it may competitively antagonize the action of calcium.
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| BCN2401 | Polyphyllin D |
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Polyphyllin D has anti-angiogenic, and anticancer effects, it induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C and cleaved-caspase-3 levels.Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis.
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| BCN2402 | Geraniin |
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Geraniin is a TNF-α releasing inhibitor with numerous activities including anticancer, anti-inflammatory, has anti-oxidant , and anti-hyperglycemic activities, with an IC50 of 43 μM. Geraniin presents radioprotective effects by regulating DNA damage on splenocytes, exerting immunostimulatory capacities and inhibiting apoptosis of radiosensitive immune cells and jejunal crypt cells. Geraniin induces Nrf2-mediated expression of antioxidant enzymes HO-1 and NQO1, presumably via PI3K/AKT and ERK1/2 signaling pathways, thereby protecting cells from H2O2-induced oxidative cell death.
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