Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC5824 | BIM 23056 |
| Somatostatin receptor ligand (Ki values are 142, > 1000, 10.8, 16.6 and 5.7 nM for human cloned sst1 - 5 receptors respectively). Behaves as an antagonist on SRIF14-induced [35S]-GTPγS binding at sst3 and sst5 receptors (PKB values are 6.33 and 5.84 respectively). | |
| BCC5837 | [Ala92]-p16 (84-103) |
| Peptide derived from the tumor suppressor protein p16; inhibits cyclin-dependent kinase-4 (cdk4)/cyclin D1 (IC50 ~ 1.5 μM) and binds to cdk6. | |
| BCC5850 | [D-Lys3]-GHRP-6 |
| Antagonist at the ghrelin receptor (GHS-R1a) (IC50 = 0.9 μM). Also weakly binds to melanocortin receptors (Ki = 26-120 μM). Centrally active in vivo. | |
| BCC5853 | N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu |
| Phosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK. | |
| BCC5854 | Neuropeptide AF (human) |
| Endogenous antiopioid peptide, implicated in pain modulation and endocrine functions. May also regulate metabolism via stimulation of β-adrenoceptor expression in adipocytes. | |
| BCC5856 | PR 39 (porcine) |
| Antibacterial peptide. Stimulates angiogenesis and inhibits inflammatory responses by selectively blocking proteasome degradation of IκBα. | |
| BCC5859 | Norketamine hydrochloride |
| Major metabolite of ketamine that is a potent non-competitive NMDA receptor antagonist (Ki = 3.6 μM for displacement of [3H]-MK 801 in rat brain). Antinociceptive and anesthetic in vivo. | |
| BCC5864 | PL 017 |
| Selective μ opioid receptor agonist (IC50 values are 5.5 and > 10000 nM for inhibition of 125I-FK 33,824 and 125I-DADLE binding to μ and δ sites respectively). Produces naloxone-reversible analgesia, catalepsy and hyperthermia following central administration in rats in vivo. | |
