Hot Natural Products & Bioactive Compounds

16 alpha-Hydroxytrametenolic acid can inhibit 12-O-tetradecanoylphorbol 13-acetate (TAP)-induced mouse ear edema.

1. Pratensein has robust activation of acetylcholinesterase expression, the induction of acetylcholinesterase included the levels of mRNA, protein and enzymatic activity.
2. Pratensein can significantly ameliorate Aβ1-42-induced spatial learning and memory impairment through reducing neuroinflammation via inhibition of glial activation and NF-κB activation, and restoring synapse and BDNF levels, suggests that administration of pratensein could likely provide a therapeutic approach for AD.
3. Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.
4. Pratensein can protect dopaminergic neurons against LPS-induced injury through inhibition of microglia activation and proinflammatory factors generation.

Isosinensetin shows antioxidant and HIV-1 protease inhibiting activities.

Eugenin is a bitter compound.

1. Jionoside A1 displays dose dependent immune-enhancement activity and possesses moderate neuroprotective activities on H2O2-treated SH-SY5Y cells.

Przewalskinic acid A is a rare, water-soluble, and highly biologically active ingredient found, thus far, only in the Salvia przewalskii Maxim herb.

1. Juncusol shows significant activity against MRSA strains.
2. Juncusol can induce caspase-3-mediated cytotoxicity in HT22 cells.
3. Juncusol shows anxiolytic and sedative activities, it shows anxiolytic activity at dosages of 10 mg/kg.

1. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis.
2. Dehydroeffusol effectively inhibits human gastric cancer cell-mediated vasculogenic mimicry with low toxicity, it is a potential drug candidate for anti-gastric cancer neovascularization and anti-gastric cancer therapy.
3. Dehydroeffusol may antagonize the spasmogenic activity of various agents, and therefore, could be a promising agent in the treatment of spasms.
4. Dehydroeffusol possesses anxiolytic and sedative properties and does not affect the general movement coordination of mice.
5. Dehydroeffusol displays enhanced antimicrobial activities in light, its antimicrobial activities (minimum inhibitory concentrations) against methicillin-resistant and -sensitive Staphylococcus aureus and Candida albicans are increased 16 fold by irradiation with ultraviolet A (UVA).