Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC5224 | Dihydroergotamine mesylate |
| Partial α-adrenergic agonist. Partial D2 dopaminergic receptor agonist. Competitive 5-HT antagonist. | |
| BCC5226 | UK 14,304 |
| Full α2 adrenergic agonist. Centrally active following systemic administration in vivo. Also available as part of the α2-Adrenoceptor and Mixed Adrenergic. Water soluble salt version UK 14,304 tartrate also available. | |
| BCC5247 | Sarpogrelate hydrochloride |
| Selective 5-HT2A receptor antagonist (pKi values are 8.52, 7.43 and 6.57 for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively). Displays selectivity over 5-HT1, 5-HT3, 5-HT4 H1, H2, M3, α1-adrenergic, α2-adrenergic and β-adrenergic receptors. Displays cardioprotective activity in vivo. | |
| BCC5267 | 4-Aminopyridine |
| Non-selective voltage-dependent K+-channel blocker (IC50 values are 170 and 230 μM at KV1.1 and KV1.2 respectively). Caged 4-AP is also available. | |
| BCC5269 | Acetaminophen |
| Cyclooxygenase inhibitor; may be selective for COX-3 (IC50 values are 460, > 1000 and > 1000 μM for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent. | |
| BCC5279 | CGP 57380 |
| Inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC50 = 2.2 μM) that displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases. Blocks phosphorylation of eIF4E in cellular assays (IC50 = 3 μM) and inhibits LPS-induced TNFα expression in macrophages. | |
| BCC5308 | Clofibrate |
| PPAR agonist (EC50 values are 50, 500 and > 100 μM at PPARα, PPARγ and PPARδ respectively). Antihyperlipoproteinemic. | |
| BCC5329 | DMH-1 |
| Selective inhibitor of the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM). Exhibits no detectable inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFRβ receptors. Blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB 431542. | |
