Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC6947 | (S)-(+)-Niguldipine hydrochloride |
| L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist; more active enantiomer. (R)-(-)-Niguldipine hydrochloride also available. | |
| BCC6948 | BRL 44408 maleate |
| Selective α2A-adrenoceptor antagonist (Ki = 1.7 nM and 144.5 nM at α2A and α2B-adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration. Also available as part of the α2-Adrenoceptor. | |
| BCC6949 | CGP 12177 hydrochloride |
| Partial agonist at β3-adrenoceptors. β1- and β2-adrenoceptor antagonist (Ki values are 0.9, 4 and 88 nM for β1, β2 and β3 receptors respectively). | |
| BCC6950 | Spermine NONOate |
| A stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC50 = 6.2 μM for relaxation of rabbit aorta, and t½ =39 min at 37°C, pH 7.4, aqueous solution). | |
| BCC6958 | DAMGO |
| Highly selective peptide agonist for the μ opioid receptor. | |
| BCC6964 | NF 279 |
| A potent and selective P2X1 antagonist (IC50 = 19 nM). Displays good selectivity over P2X2,(IC50 = 0.76 μM), P2X3 (IC50 = 1.62μM), P2X4 (IC50 > 300 μM), P2Y receptors and ecto-nucleotidases. | |
| BCC6966 | MRS 2219 |
| A selective potentiator of ATP-evoked responses at rat P2X1 receptors (EC50 = 5.9 μM). | |
| BCC6968 | SC 19220 |
| Selective EP1 receptor antagonist (IC50 = 6.7 μM for inhibition of [3H]-PGE2 binding to EP1 transfected COS cells). | |
