Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC7821 | Colivelin |
| Neuroprotective peptide and activator of STAT3. Protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer's disease (AD) models. Also prevents alcohol-induced apoptosis in a fetal mouse model. Brain penetrant. | |
| BCC7822 | TNP |
| Reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC50 = 0.47 μM for inhibition of InsP7 formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50 = 10.2 μM). Binds to the ATP binding site of IP3K (Ki = 4.3 μM). | |
| BCC7823 | exo-IWR 1 |
| Negative control for endo-IWR 1. 25-fold less active than endo-IWR 1; exhibits decreased activity against the Wnt/β-catenin pathway. | |
| BCC7826 | YIL 781 |
| Ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM). Displays no significant affinity for the motilin receptor (Ki = 6 μM). Blocks the effects of ghrelin on insulin secretion both in vivo and in vitro. Improves glucose homeostasis in vivo. | |
| BCC7827 | AR-R 17779 hydrochloride |
| Selective agonist of α7 nAChRs (Ki values are 190 and 16000 nM for rat α7 and α4β2 receptors respectively). CNS penetrant after systemic administration. | |
| BCC7828 | Tesaglitazar |
| Dual-specificity PPARα/γ agonist (IC50 values are 0.35 and 3.8 μM for PPARγ and PPARα respectively). Prevents atherosclerosis progression in E3L.CETP transgenic mice. Also reduces insulin resistance in obese Zucker rats. Orally active. | |
| BCC7829 | AA 29504 |
| Positive allosteric modulator of GABAA receptors. Modulates both α4β3δ-containing extrasynaptic receptors and α1β3γ2S-containing receptors in Xenopus oocytes, displaying a stronger modulatory effect at the former. Reduces motor coordination and exhibits anxiolytic effects in vivo. | |
| BCC7831 | Zearalenone |
| Mycotoxin produced by several species of Fusarium fungi. Binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and stimulates the transcriptional activity of both subtypes at concentrations between 1 - 10 nM. Also stimulates growth of T47D breast cancer cells. | |
