Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC7832 | Deoxynivalenol |
| Tricothecene mycotoxin and potent protein synthesis inhibitor. Exhibits cytotoxic activity in vivo via the ribotoxic stress response. Induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κB into the nucleus. | |
| BCC7833 | SR 58611A hydrochloride |
| Selective β3-adrenergic receptor agonist. Displays both anxiolytic and antidepressant effects in rodent models. Orally active and brain penetrant. | |
| BCC7839 | Cyclofenil |
| Non-steroidal selective estrogen receptor modulator (SERM). Displays higher affinity for estrogen receptor β (ERβ) than for ERα. | |
| BCC7841 | IDE 1 |
| Induces definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 125 nM). Thought to activate the TGF-β signaling pathway; induces Smad2 phosphorylation and increases levels of Nodal expression. | |
| BCC7846 | PT 1 |
| AMP-activated protein kinase (AMPK) activator. Stimulates AMPK heterotrimer (α1β1γ1) activity (EC50 = 0.3 μM). Selectively increases the activity of γ1- but not γ3-containing complexes. Thought to directly activate AMPK by antagonizing autoinhibition. | |
| BCC7848 | AC 261066 |
| Potent RARβ2 agonist (pEC50 = 8.1). Selective over RARβ1, RARα and RARγ (pEC50 values are 6.4, 6.2 and 6.3 respectively). More potent and orally available than AC 55649. | |
| BCC7853 | TCS 2510 |
| Highly selective EP4 agonist (EC50 = 2.5 nM; Ki = 1.2 nM). Displays no significant binding at other prostaglandin receptors at concentrations up to 14 μM. | |
| BCC7858 | PE 154 |
| Potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50 values are 280 pM and 16 nM respectively). Targets and labels β-amyloid plaques in histochemical analysis. | |
