Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC7785 | NF 340 |
| P2Y11 antagonist; exhibits 520-fold selectivity for P2Y11 over P2Y1, P2Y2, P2Y4, P2Y6 and P2Y12 receptors. Displays competitive antagonism against ATPγS (pIC50 values are 6.43 and 7.14 in Ca2+ and cAMP assays respectively). | |
| BCC7786 | LG 100754 |
| Novel RXR:PPARγ agonist; sensitizes PPARγ by enhancing its ligand binding activity. Also activates RXR:RAR and RXR:PPARα heterodimers in cotransfection assays. Displays selectivity over other permissive heterodimers such as RXR:LXRα and RXR:BAR/FXR. Exhibits antidiabetic properties in vivo. | |
| BCC7787 | KH 7 |
| Selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM. | |
| BCC7788 | CCMI |
| Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). Evokes positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). Exhibits cognitive-enhancing properties in rodent models; displays no cytotoxic effects in PC12 cells or rat primary cortical neurons. | |
| BCC7795 | SKF 86466 hydrochloride |
| Potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model. | |
| BCC7796 | (±)-PPCC oxalate |
| Selective sigma (σ) receptor ligand. Displays high affinity for σ1; also binds at σ2 sites (Ki = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors, DAT and SERT. | |
| BCC7798 | TCS 2210 |
| Inducer of neuronal differentiation in mesenchymal stem cells (MSCs) with specific phenotype change. Increases expression of neuronal markers β-III tubulin and NSE without cytotoxicity. | |
| BCC7799 | FFN 511 |
| Fluorescent false neurotransmitter (FFN). Targets neuronal vesicular monoamine transporter (VMAT) 2; inhibits serotonin binding to VMAT2 (IC50 = 1 μM). | |
