Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC1619 | HIV-1 integrase inhibitor 2 |
| HIV-1 integrase inhibitor 2 is an inhibitor of HIV-1 integrase used in the treatment of human immunodeficiency virus (HIV) infection | |
| BCC1623 | Hoechst 33258 |
| Fluorescent dye. Binds the minor groove of DNA at A and T rich regions. Can be used as indicator of apoptosis. | |
| BCC1629 | Hoechst 33342 |
| Cell permeable fluorescent DNA stain; binds minor groove of AT-rich regions. Used to quantify DNA in viable cells. | |
| BCC1636 | Hydroxyfasudil hydrochloride |
| Cell-permeable active metabolite of Fasudil. Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo. | |
| BCC1638 | Ibutamoren Mesylate |
| High affinity ghrelin receptor agonist (pKi = 8.14). Growth hormone (GH) secretagog; stimulates GH release from rat pituitary cells in vitro (EC50 = 1.3 nM) and enhances GH plasma levels in vivo. Also attenuates isoproterenol -induced lipolysis in rat adipocytes in vitro. Orally bioavailable. | |
| BCC1643 | IKK-3 Inhibitor |
| Potent and selective IKKε inhibitor (pIC50 = 7.4). Exhibits >100-fold selectivity for IKKε over IKKα IKKβ, and a range of other kinases. | |
| BCC1647 | INCB024360 analogue |
| Potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 values are 19 and 67 nM in enzymatic activity and HeLa cell assays, respectively). Decreases kynurenine levels in plasma and reduces tumor growth in vivo. Cell membrane permeable. | |
| BCC1655 | IRAK inhibitor 2 |
| IRAK inhibitor 2 is interleukin-1 receptor associated kinase inhibitor . | |
