Hot Natural Products & Bioactive Compounds

Nerolidol, a sesquiterpene used as a food-flavoring agent and currently under testing as a skin penetration enhancer for the transdermal delivery of therapeutic drugs. Nerolidol shows anti-cancer, sedative, antiulcer, antifungal, and antifeeding effects. Nerolidol can inhibit the growth of Leishmania amazonensis, L. braziliensis, and L. chagasi promastigotes and L. amazonensis amastigotes with in vitro 50% inhibitory concentrations of 85, 74, 75, and 67 uM, respectively.

1. Sinoacutine has protective effects against hydrogen peroxide-induced cell injury.

1. Medioresinol possesses a lesishmanicidal activity and cardiovascular disease risk reduction.
2.(+)-Medioresinol has anti-bacterial, antifungal and anti-biofilm activities.
3. Medioresinol has antioxidative activity.
4. Medioresinol has antiamyloidogenic activity via reduction in the amount of β-secretase, it is a potentially valuable antiamyloidogenic agent for the prevention and treatment of Alzheimer disease.

1. Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells.
2. Liriodenine has antiplasmodial activity.
3. Lipiferolide and epitulipinolide diepoxide possess cytotoxic activity against KB cells.

1. Skullcapflavone I selectively induces apoptosis in T-HSC/Cl-6 cells via caspase-3 and caspase-9 activation.
2. Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner.

1. Platyphyllonol-5-xylopyranoside is moderately active against KBNP-0028 (H9N2) avian influenza virus as compared with zanamivir.

1. Hirsutanonol or oregonin as an active ingredient composition for treating atopic dermatitis.
2. Hirsutanonol shows significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCF10A cells.
3. Hirsutanonol has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.
4. Hirsutanonol shows potent cytotoxic activities against murine B16 melanoma cells and human SNU-C1 gastric cancer cells.
5. Hirsutanonol has chemoprotective effect on human lymphocytes DNA.
6. Hirustenone and hirsutanonol show promising anti-filarial activity both in vitro and in vivo studies.

1. Hirsutenone exhibits anti-cancer effect against prostate cancer through a direct physical inhibition of Akt1/2.
2. Hirsutenone attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity.
3. Hirsutenone may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation.
4. Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.
5. Hirsutenone shows potent cytotoxic activities against murine B16 melanoma cells and human SNU-C1 gastric cancer cells.
6. Hirustenone and hirsutanonol show promising anti-filarial activity both in vitro and in vivo studies.