Hot Natural Products & Bioactive Compounds
BioCrick offers high-purity natural products and bioactive compounds for scientific research. Our natural product collection includes compounds derived from plants, microorganisms and other biological sources and is widely used in pharmacological, biochemical and drug discovery research.
Natural products remain an important source of bioactive molecules and drug leads. BioCrick provides researchers with high-quality natural product compounds together with catalog numbers, product information and biological activity data.
Hot Products from BioCrick
Showing 6921 - 6928 of 9359 hot products
| Catalog No. | Product Name |
|---|---|
| BCN5411 | Vincristine |
|
Vincristine-induced nociceptive painful sensation, may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action.Vincristine can treat MM, ERK1/2, Akt, and NF-κB inhibitors are potentially useful as anti-MDR agents for the treatment of Vincristine-resistant MM. An inherited polymorphism in the promoter region of CEP72 was associated with increased risk and severity of Vincristine-related peripheral neuropathy.
|
|
| BCN5412 | Rotenone |
|
Rotenone is a mitochondrial complex I inhibitor that produces an animal model of Parkinson's disease. Rotenone-induced α-synuclein aggregation is mediated by the calcium/GSK3β signaling pathway. Rotenone can increase intracellular levels of the toxic dopamine metabolite 3,4-dihydroxyphenyl-acetaldehyde (DOPAL), via decreasing DOPAL metabolism by aldehyde dehydrogenase (ALDH) and decreasing vesicular sequestration of cytoplasmic dopamine by the vesicular monoamine transporter (VMAT).
|
|
| BCN5413 | Isoforsythiaside |
|
Isoforsythiaside has antioxidant, and antibacterial activities.
|
|
| BCN5414 | Psoralidin |
|
Psoralidin possesses potent antidepressant-like, anti-inflammatory, anticancer and chemopreventive properties. Psoralidin is a dual inhibitor of COX-2 and 5-LOX, it is also an agonist for both estrogen receptor (ER)α and ERβ agonist.Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IκB signaling pathways, it induces reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells.
|
|
| BCN5415 | Isobavachalcone |
|
Isobavachalcone has anti-cancer, anthelmintic, antibacterial, aphrodisiac, anti-inflammatory, astringent and antiplatelet activities, Isobavachalcone can induce apoptotic cell death in neuroblastoma via the mitochondrial pathway; it can significantly inhibit both oligomerization and fibrillization of Aβ42; it can suppress inducible nitric oxide synthase (iNOS) expression induced by macrophage-activating lipopeptide 2-kDa, polyriboinosinic polyribocytidylic acid, or lipopolysaccharide.
|
|
| BCN5416 | Cyasterone |
|
Cyasterone, a natural EGFR inhibitor, can inhibit growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it maybe a promising anti-cancer agent; it also has antifeeding activity.
|
|
| BCN5417 | Methylophiopogonanone A |
|
Methylophiopogonanone A has anti-inflammatory and anti-oxidative properties, it also has therapeutic potential against cerebral I/R injury through its ability to attenuate BBB disruption by regulating the expression of MMP-9 and tight junction proteins.
|
|
| BCN5418 | Methylophiopogonanone B |
|
Methylophiopogonanone B has inhibition of hypoxia-inducible factor (HIF)-1 alpha activity.Methylophiopogonanone B can inhibit melanosome transfer to keratinocytes as well as melanocyte dendrite outgrowth, it also suppress pigmentation in a three-dimensional skin culture model through the inhibition of melanocyte dendrite outgrowth, it could result in the creation of very unique cosmetic products that would precisely control the darkening or lightening of skin tone.
|
|