Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC6128 | PIR 3.5 |
| Negative control of IPA 3 a direct, non-competitive inhibitor of group I p21-activated kinase (Pak1). | |
| BCC6132 | Kisspeptin 10 (rat) |
| Endogenous ligand for the rodent kisspeptin receptor (KISS1, GPR54). Rodent analog of the C-terminal KiSS-1 peptide, KiSS-1112-121 (Kisspeptin 10). | |
| BCC6133 | MRS 2957 triethylammonium salt |
| Potent P2Y6 agonist (EC50 = 12 nM). Displays 14- and 66-fold selectivity against P2Y2 and P2Y4 receptors respectively. | |
| BCC6134 | MRS 4062 triethylammonium salt |
| Selective P2Y4 receptor agonist (EC50 values are 23, 640, and 740 nM for hP2Y4, hP2Y2 and hP2Y6 respectively). | |
| BCC6135 | KH CB19 |
| Selective, potent inhibitor of CDC2-like kinase (CLK) 1 and 4 (IC50 = 20 nM for CLK1). Suppresses serine/arginine-rich protein phosphorylation by CLKs under proinflammatory conditions. Displays selectivity over a panel of 71 protein kinases. ATP-competitive. | |
| BCC6136 | PF-3644022 |
| Potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM; Ki = 3 nM). Inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM); exhibits oral efficacy in acute and chronic inflammatory models. | |
| BCC6139 | JNJ 10397049 |
| Selective OX2 receptor antagonist (pIC50 = 7.4 for chimeric OX2 receptors; pKB values are 5.9 and 8.5 for OX1 and OX2 receptors respectively). Shows no significant activity in a panel of over 50 other neurotransmitters and neuropeptide receptors. Achieves high level of OX2 receptor occupancy in the rat brain; exhibits sleep-promoting effects in rats. | |
| BCC6140 | A 784168 |
| Potent TRPV1 antagonist (IC50 = 25 nM for inhibition of TRPV1 activation by 50 nM capsaicin). Displays no activity against a range of receptors, including TRPA1, GABA, opioid, and purinergic receptors. | |
