Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC6082 | HX 531 |
| Potent RXR antagonist (IC50 = 18 nM). Promotes white and brown pre-adipocyte differentiation into white adipocytes. Also inhibits bexarotene-induced brown adipogenic reprogramming of myoblasts. | |
| BCC6083 | HX 630 |
| RXR agonist. Acts as a retinoid synergist; enhances the potency of AM 80 in a HL-60 cell differentiation assay. | |
| BCC6091 | GPi 688 |
| Allosteric glycogen phosphorylase inhibitor; acts at the indole site of glycogen phosphorylase. Inhibits glucagon-mediated hyperglycemia in vivo in the rat. | |
| BCC6093 | Nalmefene - d3 |
| Deuterated nalmefene. | |
| BCC6094 | MEN 11270 |
| Peptide antagonist of the B2 bradykinin receptor (pKi = 10.3); conformationally constrained cyclized analog of HOE 140. Blocks hypotension and bronchoconstriction in vivo. Displays selectivity for B2 over 29 other receptors and ion channels (pIC50 < 5.5). | |
| BCC6095 | PSB 0739 |
| Highly potent P2Y12 receptor antagonist (Ki = 24.9 nM). Unlike clopidogrel, does not require bioactivation. | |
| BCC6096 | Alda 1 |
| Activator of aldehyde dehydrogenase 2 (ALDH2). Increases activity of wild-type ALDH2*1 and variant ALDH2*2 (by ~2-fold and 11-fold respectively). Capable of partly restoring mutant ALDH2*2 activity; protective against cardiac ischemia. | |
| BCC6097 | EC 23 |
| Photostable synthetic retinoid; analog of ATRA. Displays similar activity to ATRA when tested on the embryonal carcinoma stem cell model TERA2.cl.SP12. Potently induces neural differentiation in human pluripotent embryonic stem cells. | |
