Home >> Research Area >>Natural Products>>Alkaloids>> Protoveratrine A

Protoveratrine A

CAS# 143-57-7

Protoveratrine A

Catalog No. BCN5346----Order now to get a substantial discount!

Product Name & Size Price Stock
Protoveratrine A: 5mg Please Inquire In Stock
Protoveratrine A: 10mg Please Inquire In Stock
Protoveratrine A: 20mg Please Inquire Please Inquire
Protoveratrine A: 50mg Please Inquire Please Inquire
Protoveratrine A: 100mg Please Inquire Please Inquire
Protoveratrine A: 200mg Please Inquire Please Inquire
Protoveratrine A: 500mg Please Inquire Please Inquire
Protoveratrine A: 1000mg Please Inquire Please Inquire

Quality Control of Protoveratrine A

Number of papers citing our products

Chemical structure

Protoveratrine A

3D structure

Chemical Properties of Protoveratrine A

Cas No. 143-57-7 SDF Download SDF
PubChem ID 8931 Appearance White powder
Formula C41H63NO14 M.Wt 793.94
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CCC(C)C(=O)OC1C(C2C(CN3CC(CCC3C2(C)O)C)C4C1(C5C(C(C6C7(C5(C4)OC6(C(CC7)OC(=O)C(C)(CC)O)O)C)OC(=O)C)OC(=O)C)O)O
Standard InChIKey HYTGGNIMZXFORS-MGYKWWNKSA-N
Standard InChI InChI=1S/C41H63NO14/c1-10-20(4)34(46)55-33-28(45)27-23(18-42-17-19(3)12-13-25(42)38(27,9)49)24-16-39-32(40(24,33)50)30(53-22(6)44)29(52-21(5)43)31-36(39,7)15-14-26(41(31,51)56-39)54-35(47)37(8,48)11-2/h19-20,23-33,45,48-51H,10-18H2,1-9H3/t19-,20+,23-,24-,25-,26-,27+,28+,29-,30+,31-,32+,33-,36-,37-,38+,39+,40-,41+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Protoveratrine A

The roots of Veratrum nigrum L.

Biological Activity of Protoveratrine A

Description1. Protoveratrine A enhances the release of acetylcholine from the nerve terminals during the resting period and at low frequency of stimulation. 2. Protoveratrine A seems to involve at least in part an inhibition of dopaminergic neuron activity. 3. Protoveratrine A has depolarizing effects on the rat diaphram. 4. Protoveratrine A has some effects on cardiovascular and respiratory systems in rats in reducing the blood pressure and heart rate,prolonging the QTc interval,decreasing the respiratory rate and increasing the respiratory width. 5. Protoveratrine A can increase K + uptake from frog skeletal muscle and cause this tissue to release more calcium (Ca ++ ). 6. Protoveratrine A has anti-hypertensive action.
TargetsCalcium Channel | Potassium Channel

Protoveratrine A Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Protoveratrine A Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Protoveratrine A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.2595 mL 6.2977 mL 12.5954 mL 25.1908 mL 31.4885 mL
5 mM 0.2519 mL 1.2595 mL 2.5191 mL 5.0382 mL 6.2977 mL
10 mM 0.126 mL 0.6298 mL 1.2595 mL 2.5191 mL 3.1489 mL
50 mM 0.0252 mL 0.126 mL 0.2519 mL 0.5038 mL 0.6298 mL
100 mM 0.0126 mL 0.063 mL 0.126 mL 0.2519 mL 0.3149 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Protoveratrine A

The alpha-naphthoxyacetic acid-elicited retching involves dopaminergic inhibition in mice.[Pubmed:7393967]

Pharmacol Biochem Behav. 1980 May;12(5):735-8.

Alpha-naphthoxyacetic acid (alpha-NOAA), one of the jumping-inducers, elicited a dose-dependent retching behavior at doses ranging from 250 to 550 mg/kg in mice and vomiting at a dose of 550 mg/kg in pigeons. Protoveratrine-A (PV-A, 0.1 mg/kg), a veratrum alkaloid, also induced retching in mice and vomiting in pigeons, while apomorphine (2 mg/kg) produced neither retching in mice nor vomiting in pigeons though it induced feeding in pigeons. The retching elicited by alpha-NOAA or PV-A was not significantly affected by scopolamine, aminooxyacetic acid and gamma-butyrolactone, but was markedly inhibited by apomorphine (2 mg/kg), this inhibitory effect being antagonized without significance by haloperidol which did not itself augment the retching. These results imply that the retching elicited by alpha-NOAA or PV-A seems to involve at least in part an inhibition of dopaminergic neuron activity.

Potentiation by crotamine of the depolarizing effects of batrachotoxin, protoveratrine A and grayanotoxin I on the rat diaphragm.[Pubmed:6312634]

Toxicon. 1983;21(4):503-14.

The interactions between crotamine and tetrodotoxin and group II sodium channel toxins, including batrachotoxin, Protoveratrine A and grayanotoxin I, were studied on the rat diaphragm muscle. When the diaphragm was pretreated with 0.1 micrograms crotamine/ml for 45 min (a condition known to depolarize the muscle by less than 3 mV, which is only 20% of the maximal depolarization induced by a saturating concentration of crotamine), the rate of depolarization by group II toxins was markedly enhanced and the time to reach the steady state depolarization was greatly shortened. The maximal depolarizations induced by each of the group II toxins, however, were not increased. Pretreatment with saturating concentrations of crotamine also caused no change of the steady state depolarization induced by batrachotoxin or grayanotoxin I. Moreover, pretreatment of the diaphragm with a high concentration of grayanotoxin I, whose effect is reversible, did not impede the depolarizing effect of crotamine. Tetrodotoxin restored the membrane potential, depolarized by crotamine, with 50% restoration at a concentration of 16 ng/ml, no matter whether a high (20 micrograms/ml) or a low (2 micrograms/ml) concentration of crotamine were used. The above results indicate that there is no competition between crotamine and group II toxins or between crotamine and tetrodotoxin. However, crotamine may affect the binding of group II toxins allosterically, increasing their affinity although the intrinsic activity may not be changed.

The effects of protoveratrine and germines on the release of acetylcholine from the Auerbach plexus of the guinea-pig ileum.[Pubmed:1159414]

J Neural Transm. 1975;37(1):43-60.

The effect of Protoveratrine A and germine-3-acetate (GMA) on the release mechanism of acetylcholine from the nerve terminals of the Auerbach plexus in the longitudinal muscle layer of the guinea-pig ileum was studied. Protoveratrine A, GMA and germine potentiated neuroeffector transmission in Auerbach's plexus in the longitudinal muscle preparation provided the neurons were stimulated at low frequencies (less than 10 Hz). Protoveratrine A and GMA enhanced the release of acetylcholine from the nerve terminals during the resting period and at low frequency of stimulation (less than 10 Hz). At continous stimulation with high frequency they were ineffective (greater than 10 Hz). When trains of 20 stimuli, with a pulse interval of 0.1 s (10 Hz) were repeatedly applied with intervals of 0.1 to 20 s between trains, the effect of GMA to increase ACh release depended on the length of the train interval; the longer the resting period between trains the higher was the output of ACh. This fact indicates that the release of ACh increased primarily during the resting periods following single stimuli or trains. The effect of GMA on ACh release proved to be highly temperature-dependent: in the presence of GMA Q10 increasing from 3.25 to 4.92. A high Ca concentration, removal of Mg or lowering of the Na concentration abolished the effect of GMA to enhance ACh release.

Keywords:

Protoveratrine A,143-57-7,Natural Products, buy Protoveratrine A , Protoveratrine A supplier , purchase Protoveratrine A , Protoveratrine A cost , Protoveratrine A manufacturer , order Protoveratrine A , high purity Protoveratrine A

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: