Calceolarioside A

CAS# 84744-28-5

Calceolarioside A

Catalog No. BCN5347----Order now to get a substantial discount!

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Calceolarioside A: 5mg Please Inquire In Stock
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Quality Control of Calceolarioside A

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Chemical structure

Calceolarioside A

3D structure

Chemical Properties of Calceolarioside A

Cas No. 84744-28-5 SDF Download SDF
PubChem ID 5273566 Appearance Light yellow powder
Formula C23H26O11 M.Wt 478.44
Type of Compound Phenylpropanoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(2R,3S,4R,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
SMILES C1=CC(=C(C=C1CCOC2C(C(C(C(O2)CO)OC(=O)C=CC3=CC(=C(C=C3)O)O)O)O)O)O
Standard InChIKey UHIGZYLCYRQESL-VJWFJHQPSA-N
Standard InChI InChI=1S/C23H26O11/c24-11-18-22(34-19(29)6-3-12-1-4-14(25)16(27)9-12)20(30)21(31)23(33-18)32-8-7-13-2-5-15(26)17(28)10-13/h1-6,9-10,18,20-28,30-31H,7-8,11H2/b6-3+/t18-,20-,21-,22-,23-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Calceolarioside A

The herbs of Ajuga becumbens Thunb.

Biological Activity of Calceolarioside A

Description1. Calceolarioside A shows potent activity against visceral leishmaniasis. 2. Calceolarioside A can induce a dose-related aggregant effect on rabbit platelets, which may be partly related to a calcium-dependent mechanism. 3. Calceolarioside A has potent antioxidative activity, it displays stronger scavenging potential with IC50 values of (4.15 +/- 0.07, 40.32 +/- 0.09, 2.26 +/- 0.03 microM) for OH, total ROS and scavenging of ONOO(-), respectively.
TargetsCalcium Channel | Antifection

Calceolarioside A Dilution Calculator

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Calceolarioside A Molarity Calculator

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Preparing Stock Solutions of Calceolarioside A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0901 mL 10.4506 mL 20.9013 mL 41.8025 mL 52.2532 mL
5 mM 0.418 mL 2.0901 mL 4.1803 mL 8.3605 mL 10.4506 mL
10 mM 0.209 mL 1.0451 mL 2.0901 mL 4.1803 mL 5.2253 mL
50 mM 0.0418 mL 0.209 mL 0.418 mL 0.8361 mL 1.0451 mL
100 mM 0.0209 mL 0.1045 mL 0.209 mL 0.418 mL 0.5225 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Calceolarioside A

In vivo efficacy of calceolarioside A against experimental visceral leishmaniasis.[Pubmed:18543147]

Planta Med. 2008 Apr;74(5):503-8.

Bioactivity-guided fractionation has led to the successful isolation of Calceolarioside A ( 1) from the methanolic extract of night jasmine leaves. The in vitro antileishmanial activity of compound 1 was determined (IC (50) = 20 microg/mL). Its IN VIVO efficacy was noted at 20 mg/kg body weight when it reduced the hepatic and splenic parasite burden by 79 and 84 %, respectively, in an established model of L. donovani Ag83 infected golden hamster. Furthermore, synergistic potentiations of compound 1 at 20 mg/kg body weight and SAG at 5 mg/kg body weight showed a significant reduction of hepatic and splenic parasite burden. No cytotoxicity was observed against the U937 cell line. This is the first report describing the isolation of compound 1 from N. arbor-tristis L. and the first demonstration of its potent activity against visceral leishmaniasis.

Antioxidant phenylpropanoid glycosides from Buddleja davidii.[Pubmed:19548780]

J Enzyme Inhib Med Chem. 2009 Aug;24(4):993-7.

Phytochemical investigations on the n-BuOH-soluble fraction of the whole plant of Buddleja davidii led to the isolation of the phenylpropanoid glycosides 1-10. Their structures were determined by 1D and 2D NMR spectroscopic techniques. All the compounds showed potent antioxidative activity in three different tests, with IC(50) values in the range 4.15-9.47 microM in the hydroxyl radical ( OH) inhibitory activity test, 40.32-81.15 microM in the total ROS (reactive oxygen species) inhibitory activity test, and 2.26-7.79 microM in the peroxynitrite (ONOO(-)) scavenging activity test. Calceolarioside A (1) displayed the strongest scavenging potential with IC(50) values of (4.15 +/- 0.07, 40.32 +/- 0.09, 2.26 +/- 0.03 microM) for OH, total ROS and scavenging of ONOO(-), respectively.

Platelet aggregation induced by calceolarioside A in vitro: role of platelet intracellular calcium.[Pubmed:8372152]

Planta Med. 1993 Aug;59(4):337-9.

The effect of Calceolarioside A, a phenylpropanoid glycoside (PhG), isolated from Calceolaria hypericina, was studied on rabbit platelets in vitro. Calceolarioside A induced a dose-related aggregant effect on rabbit platelets. Indomethacin did not modify the Calceolarioside A-induced aggregant effect. Furthermore, no modification was exerted by phenoxybenzamine, BW 577C, and WEB 2086 on the PhG aggregant effect. On the contrary, TMB-8, an intracellular calcium blocker, significantly reduced the PhG effect. The latter result suggests that Calceolarioside A aggregation may be partly related to a calcium-dependent mechanism.

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