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Lorcaserin HCl

CAS# 846589-98-8

Lorcaserin HCl

Catalog No. BCC5041----Order now to get a substantial discount!

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Lorcaserin HCl: 5mg $58 In Stock
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Chemical structure

Lorcaserin HCl

3D structure

Chemical Properties of Lorcaserin HCl

Cas No. 846589-98-8 SDF Download SDF
PubChem ID 11673085 Appearance Powder
Formula C11H15Cl2N M.Wt 232.15
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble in DMSO > 10 mM
Chemical Name (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine;hydrochloride
SMILES CC1CNCCC2=C1C=C(C=C2)Cl.Cl
Standard InChIKey ITIHHRMYZPNGRC-QRPNPIFTSA-N
Standard InChI InChI=1S/C11H14ClN.ClH/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9;/h2-3,6,8,13H,4-5,7H2,1H3;1H/t8-;/m0./s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Lorcaserin HCl Dilution Calculator

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Lorcaserin HCl Molarity Calculator

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Preparing Stock Solutions of Lorcaserin HCl

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.3076 mL 21.5378 mL 43.0756 mL 86.1512 mL 107.689 mL
5 mM 0.8615 mL 4.3076 mL 8.6151 mL 17.2302 mL 21.5378 mL
10 mM 0.4308 mL 2.1538 mL 4.3076 mL 8.6151 mL 10.7689 mL
50 mM 0.0862 mL 0.4308 mL 0.8615 mL 1.723 mL 2.1538 mL
100 mM 0.0431 mL 0.2154 mL 0.4308 mL 0.8615 mL 1.0769 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Lorcaserin HCl

selective full agonist of human 5-HT2C receptor with Ki of 15 nM.

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References on Lorcaserin HCl

Lorcaserin Hcl for the treatment of obesity.[Pubmed:26472579]

Expert Opin Pharmacother. 2015;16(16):2531-8.

INTRODUCTION: Obesity is a major health priority necessitating safe and effective strategies to address the obesity epidemic. Lorcaserin is a serotonergic agonist specific to the 5HT- 2C receptor approved for chronic management of obesity in patients with a BMI >/= 30 kg/m(2) or a BMI >/= 27 kg/m(2) with comorbidities related to obesity. AREAS COVERED: In this paper, the pharmacodynamic and pharmacokinetic properties of lorcaserin are reviewed followed by a discussion of efficacy and safety data from major clinical trials. EXPERT OPINION: Lorcaserin is a unique highly selective serotonergic agonist designed to mitigate the risks associated with previous agents in this class. At therapeutic doses, it is well tolerated and produces modest but clinically meaningful weight loss with significant improvement in cardiometabolic parameters. Therapeutic efficacy should be assessed at 12 weeks (>/= 5% weight loss) to identify responders who will derive maximum weight loss and metabolic benefit from long-term therapy. The results of the ongoing cardiovascular outcomes trial (CAMELLIA TIMI 61) will determine the role of lorcaserin in primary prevention of diabetes in overweight/obese individuals and its use in the high-risk population of patients with established cardiovascular disease or multiple cardiovascular risk factors.

Description

Lorcaserin (Hydrochloride) is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM.

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