Enalaprilat DihydrateCAS# 84680-54-6 |
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Quality Control & MSDS
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| Cas No. | 84680-54-6 | SDF | Download SDF |
| PubChem ID | 55286 | Appearance | Powder |
| Formula | C18H28N2O7 | M.Wt | 384.42 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 100 mg/mL (260.13 mM) H2O : 12.5 mg/mL (32.52 mM; Need ultrasonic) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 2-[2-[(1-carboxy-3-phenylpropyl)amino]propanoyl]pyrrolidine-1-carboxylic acid;dihydrate | ||
| SMILES | CC(C(=O)C1CCCN1C(=O)O)NC(CCC2=CC=CC=C2)C(=O)O.O.O | ||
| Standard InChIKey | LRBNLIUVJIKAQR-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C18H24N2O5.2H2O/c1-12(16(21)15-8-5-11-20(15)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13;;/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25);2*1H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.
Target: ACE
Enalaprilat has high affinity for human endothelial ACE with IC50 of 1.94 nM in vitro binding assay by displacing a saturating concentration of [125I]351A, a radiolabeled lisinopril analogue from ACE binding sites, and shows bradykinin/angiotensin I selectivity ratio of 1.00 calculated from double displacement experiments [1]. Enalaprilat attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with IC50 of 90 mM [2].
Administration of Enalaprilat induces a significant reduction of MAP at 70 minutes compared with the placebo group during haemorrhagic shock in rats, and results in a 50% reduction of CO, a general tendency of EB extravasation which is significant in the kidney and lungs, and a significant increase in ileal EB extravasation (53%) [3]. References: | |||||
Enalaprilat Dihydrate Dilution Calculator
Enalaprilat Dihydrate Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6013 mL | 13.0066 mL | 26.0132 mL | 52.0264 mL | 65.033 mL |
| 5 mM | 0.5203 mL | 2.6013 mL | 5.2026 mL | 10.4053 mL | 13.0066 mL |
| 10 mM | 0.2601 mL | 1.3007 mL | 2.6013 mL | 5.2026 mL | 6.5033 mL |
| 50 mM | 0.052 mL | 0.2601 mL | 0.5203 mL | 1.0405 mL | 1.3007 mL |
| 100 mM | 0.026 mL | 0.1301 mL | 0.2601 mL | 0.5203 mL | 0.6503 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.
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Enalaprilat dihydrate (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.
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