Hot Natural Products & Bioactive Compounds

1. 3-Methoxyfuran shows Diels-Alder reactivity under forcing conditions.

Flavokawain A is an apoptotic inducer and immune- modulator ,it also shows anti-inflammatory, and anti-tumor activities.Flavokawain A can significantly reduce the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and cause cyclin B1 protein accumulation leading to CDK1 activation in T24 cells.Flavokawain A may suppress LPS-induced expression of pro-inflammatory mediators via blockage of NF-κB-AP-1-JNK/p38 MAPK signaling pathways in the murine macrophages.

1. Gardneramine and hirsutine show a local anesthetic action, they also can inhibit the ganglionic transmission of the dog urinary bladder and that the blockade of the nicotinic receptor plays a main role.
2. Gardneramine has a mild central depressive effect.

Chelerythrine is a well-known protein kinase C inhibitor, can inhibit telomerase activity, it also can block the human P2X 7 receptor. Chelerythrine has antimanic, potential antiproliferative and antitumor effects, it has significant cytotoxic effect, independent of p53 and androgen status, on human prostate cancer cell lines.

1. Isoapetalic acid and apetalic acid exhibit cytotoxic activities towards both cancer cell lines(human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines) and both Gram-positive bacteria(two Gram-positive bacteria, S. aureus and B. subtilis and two Gram-negative bacteria, P. aeruginosa and E. coli.).

1. Lyoniside and saracoside are cytotoxic to promastigotes and intracellular amastigotes, they demonstrate strong anti-leishmanial efficacies in BALB/c mice model of leishmaniasis, suggests that these two compounds potential anti-leishmanial candidates.
2. The synergistic action of lyoniside and triterpene acids was demonstrated in inhibitory effect exerted on germination and growth of Pinus sylvestris .

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1. (+)-Nortrachelogenin shows effects on the central nervous system producing depression in rabbits.
2. (-)-Nortrachelogenin can induce membrane disruption and caspase-dependent apoptosis.
3. Nortrachelogenin shows anti-plasmodium activity of 14.50 dg/ml.
4. Nortrachelogenin has anti-inflammatory properties.
5. Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth factor receptors, thereby efficiently synergizing with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), exposure.
6. (-)-Nortrachelogenin exerts its antibacterial effect by disorganizing and perturbing the cytoplasmic membrane.
7. (+)-Nortrachelogenin is moderately active against HIV-1 in vitro.
8. Nortrachelogenin shows moderate inhibiting activities on NF- κB signaling pathway induced by TNFα , with the IC50 value of 49.4 uM.