Hot Natural Products & Bioactive Compounds

Arjunic acid is a strong antioxidant and a free radical scavenger.
Arjunic acid shows activity against Gram-positive and Gram-negative bacteria with MIC values ranging between 1.9 and 15.6 microg/mL.

1. Isotachioside has15-lipoxygenase (15-LO) inhibitory activities.

1. Sutherlandin trans-p-coumarate is a naturally rare cyanogenic glycoside.

Isobavachin can stimulate osteoblasts proliferation and differentiation; it also can facilitate mouse embryonic stem cells differentiating into neuronal cells, the mechanism involved protein prenylation and, subsequently, phos-ERK activation and the phos-p38 off pathway. Isobavachin possesses estrogen-like activity in MCF-7/BOS cells, it can significantly stimulate the proliferation of MCF-7/BOS cells in a dose-dependent manner. Isobavachin has cytotoxic effects on H4IIE hepatoma and metabolically poorly active C6 glioma cells.

1. Heraclenol is a germination inhibitor in the parsley seeds.
2. Heraclenol has anti-inflammatory properties against the ear edema in mice produced by TPA.
3. Heraclenol and heraclenin inhibit the proliferation of melanoma cells and cell cycle at G2/M at concentrations of 0.1-1.0 uM.

6-Methoxywogonin shows weak anti-inflammatory effect.

1. Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension .
2. Pinusolide has antileukemic potential, it not only decreases the proliferation activity of tumor cells at relatively low concentrations but specifically induces apoptosis at 100 microM via the mitochondrial pathway in the Burkitt lymphoma cell line BJAB.
3. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes.
4. Pinusolide can protect neuronal cells from staurosporine (STS) -induced apoptosis, probably by preventing the increase in [Ca2+]i and cellular oxidation caused by STS, and indicate that it could be used to treat neurodegenerative diseases.
5. Pinusolide shows potent inhibition of 5-LO dependent LTC4 generation, which requires both suppression of calcium influx and JNK phosphorylation.

1. Hesperetin 7-O-glucoside can reduce blood pressure in healthy volunteers.
2. Hesperetin 7-O-glucoside shows inhibition of human HMG-CoA reductase, it also exhibits effective inhibition of the growth of Helicobacter pylori.
3. Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium.