ML 213

KV7.2 and KV7.4 channel opener CAS# 489402-47-3

ML 213

Catalog No. BCC6213----Order now to get a substantial discount!

Product Name & Size Price Stock
ML 213: 5mg $92 In Stock
ML 213: 10mg Please Inquire In Stock
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Quality Control of ML 213

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Chemical structure

ML 213

3D structure

Chemical Properties of ML 213

Cas No. 489402-47-3 SDF Download SDF
PubChem ID 3111211 Appearance Powder
Formula C17H23NO M.Wt 257.37
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : 30 mg/mL (116.56 mM; Need ultrasonic and warming)
Chemical Name N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-3-carboxamide
SMILES CC1=CC(=C(C(=C1)C)NC(=O)C2CC3CCC2C3)C
Standard InChIKey SIQGKPGBLYKQBB-UHFFFAOYSA-N
Standard InChI InChI=1S/C17H23NO/c1-10-6-11(2)16(12(3)7-10)18-17(19)15-9-13-4-5-14(15)8-13/h6-7,13-15H,4-5,8-9H2,1-3H3,(H,18,19)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of ML 213

DescriptionSelective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). Displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay.

ML 213 Dilution Calculator

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ML 213 Molarity Calculator

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Preparing Stock Solutions of ML 213

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.8855 mL 19.4273 mL 38.8546 mL 77.7091 mL 97.1364 mL
5 mM 0.7771 mL 3.8855 mL 7.7709 mL 15.5418 mL 19.4273 mL
10 mM 0.3885 mL 1.9427 mL 3.8855 mL 7.7709 mL 9.7136 mL
50 mM 0.0777 mL 0.3885 mL 0.7771 mL 1.5542 mL 1.9427 mL
100 mM 0.0389 mL 0.1943 mL 0.3885 mL 0.7771 mL 0.9714 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on ML 213

An Update on the Genetic Polymorphism of HLA-B*27 With 213 Alleles Encompassing 160 Subtypes (and Still Counting).[Pubmed:28247302]

Curr Rheumatol Rep. 2017 Feb;19(2):9.

PURPOSE OF REVIEW: This publication updates an earlier review on the ever increasing knowledge about genetic polymorphism of HLA-B*27 and discusses its clinical relevance. RECENT FINDINGS: As of January 1, 2017, there are 213 known alleles of HLA-B*27 at nucleotide sequence level, while at the translated protein level, there are 160 known subtypes based on one or more amino acid sequence differences. Some of these subtypes exhibit differential association with ankylosing spondylitis, and there may even be some level of hierarchy in this regard. On the other hand, HLA-B*27 has a protective effect against HCV, and this effect is also influenced by some of the subtypes of HLA-B*27. This may have important implications for designing anti-viral vaccines for global population and also for developing individualized treatments and vaccines. Disease association and disease protective roles of HLA-B*27 suggest a common ground, i.e., promoting a more pronounced immune/inflammatory response for effective clearance of some pathogens, but that might, on the other hand, lead to autoimmunity and tissue injury in some circumstances.

Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener.[Pubmed:22125664]

ACS Chem Neurosci. 2011 Oct 19;2(10):572-577.

Herein we report the discovery, synthesis and evaluation of a series of N-Aryl-bicyclo[2.2.1]heptane-2-carboxamides as selective KCNQ2 (K(v)7.2) and KCNQ4 (K(v)7.4) channel openers. The best compound, 1 (ML213) has an EC(50) of 230 nM (KCNQ2) and 510 nM (KCNQ4) and is selective for KCNQ2 and KCNQ4 channels versus a large battery of related potassium channels, as well as affording modest brain levels. This represents the first report of unique selectivity profile for KCNQ2 and KCNQ4 over the other channels (KCNQ1/3/5) and as such should prove to be a valuable tool compound for understanding these channels in regulating neuronal activity.

Description

ML213 is a selective activator of Kv7.2 and Kv7.4 channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively.

Keywords:

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