Home >> Research Area >> SBC-115076

SBC-115076

Anti-PCSK9 compound CAS# 489415-96-5

SBC-115076

Catalog No. BCC6440----Order now to get a substantial discount!

Product Name & Size Price Stock
SBC-115076: 5mg $161 In Stock
SBC-115076: 10mg Please Inquire In Stock
SBC-115076: 20mg Please Inquire Please Inquire
SBC-115076: 50mg Please Inquire Please Inquire
SBC-115076: 100mg Please Inquire Please Inquire
SBC-115076: 200mg Please Inquire Please Inquire
SBC-115076: 500mg Please Inquire Please Inquire
SBC-115076: 1000mg Please Inquire Please Inquire
Related Products
  • SB 431542

    Catalog No.:BCC3658
    CAS No.:301836-41-9
  • GW788388

    Catalog No.:BCC3666
    CAS No.:452342-67-5
  • A 77-01

    Catalog No.:BCC1318
    CAS No.:607737-87-1
  • SD-208

    Catalog No.:BCC1938
    CAS No.:627536-09-8
  • LY2157299

    Catalog No.:BCC3709
    CAS No.:700874-72-2
  • A 83-01

    Catalog No.:BCC1319
    CAS No.:909910-43-6

Quality Control of SBC-115076

Number of papers citing our products

Chemical structure

SBC-115076

3D structure

Chemical Properties of SBC-115076

Cas No. 489415-96-5 SDF Download SDF
PubChem ID 5734410 Appearance Powder
Formula C31H33N3O5 M.Wt 527.61
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : ≥ 32 mg/mL (60.65 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name 4-[hydroxy-(3-methyl-4-phenylmethoxyphenyl)methylidene]-1-(3-morpholin-4-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione
SMILES CC1=C(C=CC(=C1)C(=C2C(N(C(=O)C2=O)CCCN3CCOCC3)C4=CC=NC=C4)O)OCC5=CC=CC=C5
Standard InChIKey VVYIXKBHQQSREP-UHFFFAOYSA-N
Standard InChI InChI=1S/C31H33N3O5/c1-22-20-25(8-9-26(22)39-21-23-6-3-2-4-7-23)29(35)27-28(24-10-12-32-13-11-24)34(31(37)30(27)36)15-5-14-33-16-18-38-19-17-33/h2-4,6-13,20,28,35H,5,14-19,21H2,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of SBC-115076

DescriptionSBC-115076 is an anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds, for the treatment and/or prevention of cardiovascular diseases. Target: PCSK9 in vivo: SBC-115076 lowers cholesterol levels in mice that are fed high fat diet.

References:
[1]. Abdel-Meguid, et al. Anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases

SBC-115076 Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

SBC-115076 Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of SBC-115076

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.8953 mL 9.4767 mL 18.9534 mL 37.9068 mL 47.3835 mL
5 mM 0.3791 mL 1.8953 mL 3.7907 mL 7.5814 mL 9.4767 mL
10 mM 0.1895 mL 0.9477 mL 1.8953 mL 3.7907 mL 4.7383 mL
50 mM 0.0379 mL 0.1895 mL 0.3791 mL 0.7581 mL 0.9477 mL
100 mM 0.019 mL 0.0948 mL 0.1895 mL 0.3791 mL 0.4738 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on SBC-115076

Description:

IC50: N/A

PCSK9 is a serine protease mainly expressed in the liver and the intestine. It acts by reducing the amount of LDLR in hepatocytes. PCSK9 enzymatic activity permits its intracellular maturation, followed by secretion. Circulating PCSK9 binds the LDLR on the cell surface and is subsequently cointernalized together with the LDLR. PCSK9 can also bind the LDLR intracellularly. Thus, by virtue of its role as a major inhibitor of the LDLR, PCSK9 has emerged as a hot new drug target to treat hypercholesterolemia and coronary heart disease. SBC-115076 is an anti-PCSK9 compound.

In vitro: It was found that SBC-115076 could dose-dependently increase the DHLDL uptake, which was lower than that SBC-110034 did. Moreover, SBC-115076 could increase several folds of the intracellular LDLR level at 1.6 μM [1].

In vivo: SBC-115076 was observed to lower cholesterol levels in mice that were fed high fat diet. Results showed data obtained with SBC-115076 indicating a mean of 32% reduction in total cholesterol levels after two weeks relative to high fat diet animal levels and a mean 50% reduction toward return to regular diet cholesterol levels [1].

Clinical trial: Up to now, SBC-115076 is still in the preclinical development stage.

Reference:
[1] Anti-proprotein convertase subtilisin kexin type 9 (anti-pcsk9) compounds and methods of using the same in the treatment and/or prevention of cardiovascular diseases.  Patent: WO 2014150326 A1

Featured Products
New Products
 

Description

SBC-115076 is an anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds, for the treatment and/or prevention of cardiovascular diseases.

Keywords:

SBC-115076,489415-96-5,Natural Products, buy SBC-115076 , SBC-115076 supplier , purchase SBC-115076 , SBC-115076 cost , SBC-115076 manufacturer , order SBC-115076 , high purity SBC-115076

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: