Gossypetin

CAS# 489-35-0

Gossypetin

Catalog No. BCN8075----Order now to get a substantial discount!

Product Name & Size Price Stock
Gossypetin: 5mg Please Inquire In Stock
Gossypetin: 10mg Please Inquire In Stock
Gossypetin: 20mg Please Inquire Please Inquire
Gossypetin: 50mg Please Inquire Please Inquire
Gossypetin: 100mg Please Inquire Please Inquire
Gossypetin: 200mg Please Inquire Please Inquire
Gossypetin: 500mg Please Inquire Please Inquire
Gossypetin: 1000mg Please Inquire Please Inquire

Quality Control of Gossypetin

Number of papers citing our products

Chemical structure

Gossypetin

3D structure

Chemical Properties of Gossypetin

Cas No. 489-35-0 SDF Download SDF
PubChem ID 5280647 Appearance Yellow Crystalline
Formula C15H10O8 M.Wt 318.24
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxychromen-4-one
SMILES C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C(=C(C=C3O)O)O)O)O)O
Standard InChIKey YRRAGUMVDQQZIY-UHFFFAOYSA-N
Standard InChI InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)14-13(22)12(21)10-8(18)4-9(19)11(20)15(10)23-14/h1-4,16-20,22H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Gossypetin

The herbs of Rhodiola rosea

Biological Activity of Gossypetin

Description1. Gossypetin has anti-mutagenic, anti-atherosclerotic, antioxidant, as well as cytoprotective and antimicrobial effects. 2. Gossypetin inhibits bone resorption through down-regulating lysosomal cathepsin K activity and autophagy-related protein induction in actin ring-bearing osteoclasts. 3. Gossypetin ameliorates ionizing radiation-induced oxidative stress in mice liver, it shows radioprotective action against gamma (γ)-radiation-induced oxidative stress. 4. Gossypetin is an inducer of apoptotic and autophagic cell death in LNCaP cells, and provide a new mechanism for its anticancer activity.
TargetsPI3K | ATPase | MMP(e.g.TIMP) | NF-kB | Nrf2 | JNK

Gossypetin Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Gossypetin Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Gossypetin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.1423 mL 15.7114 mL 31.4228 mL 62.8457 mL 78.5571 mL
5 mM 0.6285 mL 3.1423 mL 6.2846 mL 12.5691 mL 15.7114 mL
10 mM 0.3142 mL 1.5711 mL 3.1423 mL 6.2846 mL 7.8557 mL
50 mM 0.0628 mL 0.3142 mL 0.6285 mL 1.2569 mL 1.5711 mL
100 mM 0.0314 mL 0.1571 mL 0.3142 mL 0.6285 mL 0.7856 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Gossypetin

Anti-prostate cancer potential of gossypetin via inducing apoptotic and autophagic cell death.[Pubmed:28671312]

Mol Carcinog. 2017 Dec;56(12):2578-2592.

Gossypetin (GTIN), a naturally occurring hexahydroxy flavone, has been shown to possess antimutagenic, antioxidant, antimicrobial, and antiatherosclerotic effects. Here, we investigated the mechanism(s) underlying the anticancer potential of GTIN. In this study, investigations were showed that GTIN preferentially induces programed cell death of prostate cancer (PCa) cells in vitro and in vivo. MTT data showed that GTIN exhibited the anti-proliferation effect on human PCa cells in a dose- and time-dependent manner. Among two kinds of PCa cells, androgen-dependent LNCaP cells were the most susceptible to GTIN. GTIN was evaluated for apoptotic and autophagic activities in LNCaP cells, but not in androgen-independent DU145 cells with mutant Atg5 and resistant to autophagy. Molecular data showed the apoptotic effect of GTIN at a high dose in PCa cells might be mediated via mitochondrial pathway. The lower dose of GTIN-induced autophagy enhances LNCaP cell death, and is dependent on class III PI3K and Atg5 pathway. Finally, GTIN was evidenced by its inhibition on the growth of LNCaP cells in xenograft tumor studies. As a result, our data presented the first evidence of GTIN as an inducer of apoptotic and autophagic cell death in LNCaP cells, and provide a new mechanism for its anticancer activity.

Gossypetin ameliorates ionizing radiation-induced oxidative stress in mice liver--a molecular approach.[Pubmed:25994373]

Free Radic Res. 2015 Oct;49(10):1173-86.

Radioprotective action of Gossypetin (GTIN) against gamma (gamma)-radiation-induced oxidative stress in liver was explored in the present article. Our main aim was to evaluate the protective efficacy of GTIN against radiation-induced alteration of liver in murine system. To evaluate the effect of GTIN, it was orally administered to mice at a dose of 30 mg/kg body weight for three consecutive days prior to gamma-radiation at a dose of 5 Gy. Radioprotective efficacy of GTIN were evaluated at physiological, cellular, and molecular level using biochemical analysis, comet assay, flow cytometry, histopathology, immunofluorescence, and immunoblotting techniques. Ionizing radiation was responsible for augmentation of hepatic oxidative stress in terms of lipid peroxidation and depletion of endogenous antioxidant enzymes. Immunoblotting and immunofluorescence studies showed that irradiation enhanced the nuclear translocation of nuclear factor kappa B (NF-kappaB) level, which leads to hepatic inflammation. To investigate further, we found that radiation induced the activation of stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK)-mediated apoptotic pathway and deactivation of the NF-E2-related factor 2 (Nrf2)-mediated redox signaling pathway, whereas GTIN pretreatment ameliorated these radiation-mediated effects. This is the novel report where GTIN rationally validated the molecular mechanism in terms of the modulation of cellular signaling system' instead of ' This is the novel report where GTIN is rationally validated in molecular terms to establish it as promising radioprotective agents. This might be fruitful especially for nuclear workers and defense personnel assuming the possibility of radiation exposure.

Description

Gossypetin is a hexahydroxylated flavonoid and is a potent mitogen-activated protein kinase kinase (MKK)3 and MKK6 inhibitor with strongly attenuates the MKK3/6-p38 signaling pathway, has various pharmacological activities, including antioxidant, antibacterial and anticancer activities.

Keywords:

Gossypetin,489-35-0,Natural Products, buy Gossypetin , Gossypetin supplier , purchase Gossypetin , Gossypetin cost , Gossypetin manufacturer , order Gossypetin , high purity Gossypetin

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: