HeleurineCAS# 488-00-6 |
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| Cas No. | 488-00-6 | SDF | Download SDF |
| PubChem ID | 10259 | Appearance | Powder |
| Formula | C16H27NO4 | M.Wt | 297.39 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5,6,7,8-tetrahydro-3H-pyrrolizin-1-ylmethyl 2-hydroxy-2-(1-methoxyethyl)-3-methylbutanoate | ||
| SMILES | CC(C)C(C(C)OC)(C(=O)OCC1=CCN2C1CCC2)O | ||
| Standard InChIKey | AORFDVNAPHMKAU-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C16H27NO4/c1-11(2)16(19,12(3)20-4)15(18)21-10-13-7-9-17-8-5-6-14(13)17/h7,11-12,14,19H,5-6,8-10H2,1-4H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Heliotropium indicum L.
| Description | 1. Heleurine, platyphylline, supinine and cynaustraline are more potent in antagonizing responses to acetylcholine and carbachol than responses to histamine. |
| Targets | AChR |
Heleurine Dilution Calculator
Heleurine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3626 mL | 16.8129 mL | 33.6259 mL | 67.2518 mL | 84.0647 mL |
| 5 mM | 0.6725 mL | 3.3626 mL | 6.7252 mL | 13.4504 mL | 16.8129 mL |
| 10 mM | 0.3363 mL | 1.6813 mL | 3.3626 mL | 6.7252 mL | 8.4065 mL |
| 50 mM | 0.0673 mL | 0.3363 mL | 0.6725 mL | 1.345 mL | 1.6813 mL |
| 100 mM | 0.0336 mL | 0.1681 mL | 0.3363 mL | 0.6725 mL | 0.8406 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Pyrrolizidine alkaloids: actions on muscarinic receptors in the guinea-pig ileum.[Pubmed:5579465]
Br J Pharmacol. 1971 Apr;41(4):683-90.
1. Eleven pyrrolizidine alkaloids have been tested on the isolated guinea-pig ileum preparation.2. Platyphylline, supinine, Heleurine and cynaustraline were more potent in antagonizing responses to acetylcholine and carbachol than responses to histamine. Their anticholinergic activity appeared to involve a competitive mechanism.3. Lasiocarpine, monocrotaline, spectabiline, sarracine, 7-angelylheliotridine, heliotrine and senecionine had similar antagonistic potencies against responses to both acetylcholine and histamine.4. The alkaloids had no appreciable activity as antagonists of acetylcholine in the isolated toad rectus abdominis preparation.5. These results are discussed with respect to interactions of the alkaloids at receptor sites involved in anticholinergic activity at the muscarinic receptor.
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