Hot Natural Products & Bioactive Compounds

Forsythoside H is a nartural product from Forsythia suspense (Thunb.) Vahl.

1. D-(+)-Fucose is a hexose deoxy sugar found on N-linked glycans that appears on the cell surface of mammalian and plant cells.

1. Kaji-ichigoside F1 exhibits in vivo hepatoprotective effects, it inhibited d-GalN-induced cytotoxicity in primary cultured mouse hepatocytes with the IC50 of14.1uM.
2. Kaji-ichigoside F1 shows antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats.

1. Notoginsenoside Ft1 may accelerate diabetic wound healing by orchestrating multiple processes, including promoting fibroblast proliferation, enhancing angiogenesis, and attenuating inflammatory response, which provided a great potential application of it in clinics for patients with diabetic foot ulcers.
2. Notoginsenoside Ft1 can arrest the proliferation and elicited the apoptosis of SH-SY5Y cells possibly via p38 MAPK and ERK1/2 pathways, which indicates the potential therapeutic effect of it on human neuroblastoma.
3. Notoginsenoside Ft1 activates both glucocorticoid and estrogen receptors to induce endothelium-dependent, nitric oxide-mediated relaxations in rat mesenteric arteries.
4. Notoginsenoside Ft1 can enhance platelet aggregation by activating a signalling network mediated through P2Y₁₂ receptors.
5. Notoginsenoside Ft1 is a novel stimulator of angiogenesis, it stimulates angiogenesis via HIF-1α-mediated VEGF expression, with PI3K/AKT and Raf/MEK/ERK signaling cascades concurrently participating in the process.

1. Icariside F2 displays potent NF-κB inhibitory effects, with the IC50 value of 16.25 ± 2.19 uM.
2. Icariside F2 shows modest α-glucosidase inhibitory (4.60±1.74% to 11.97±3.30%) and antioxidant activities.

6-Formyl-1,2,9,10-tetramethoxy-6a,7-dehydroaporphine is a natural product from Aconitum carmichaelii.

1. Guajadial F shows cytotoxicity against five human cancer cell lines.
2. Guajadial F acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage.

1. Flavidin shows very good antioxidant capacity.
2. Flavidin can enhance fluorescent imaging, allowing more sensitive and specific cell labeling in tissues, it should have wide application in molecular detection, providing a general insight into how to optimize simultaneously the behavior of the biomolecule and the chemical probe.