Icariside F2

CAS# 115009-57-9

Icariside F2

Catalog No. BCN6435----Order now to get a substantial discount!

Product Name & Size Price Stock
Icariside F2: 5mg $725 In Stock
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Quality Control of Icariside F2

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Chemical structure

Icariside F2

3D structure

Chemical Properties of Icariside F2

Cas No. 115009-57-9 SDF Download SDF
PubChem ID 14079045 Appearance Oil
Formula C18H26O10 M.Wt 402.39
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2R,3S,4S,5R,6R)-2-[[(2R,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-6-phenylmethoxyoxane-3,4,5-triol
SMILES C1C(C(C(O1)OCC2C(C(C(C(O2)OCC3=CC=CC=C3)O)O)O)O)(CO)O
Standard InChIKey NJMQSVWMCODQIP-FQXXIRCGSA-N
Standard InChI InChI=1S/C18H26O10/c19-8-18(24)9-27-17(15(18)23)26-7-11-12(20)13(21)14(22)16(28-11)25-6-10-4-2-1-3-5-10/h1-5,11-17,19-24H,6-9H2/t11-,12-,13+,14-,15+,16-,17-,18-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Icariside F2

The leaves of Piper retrofractum.

Biological Activity of Icariside F2

Description1. Icariside F2 displays potent NF-κB inhibitory effects, with the IC50 value of 16.25 ± 2.19 uM. 2. Icariside F2 shows modest α-glucosidase inhibitory (4.60±1.74% to 11.97±3.30%) and antioxidant activities.
TargetsNF-kB

Icariside F2 Dilution Calculator

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Icariside F2 Molarity Calculator

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Preparing Stock Solutions of Icariside F2

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4852 mL 12.4258 mL 24.8515 mL 49.703 mL 62.1288 mL
5 mM 0.497 mL 2.4852 mL 4.9703 mL 9.9406 mL 12.4258 mL
10 mM 0.2485 mL 1.2426 mL 2.4852 mL 4.9703 mL 6.2129 mL
50 mM 0.0497 mL 0.2485 mL 0.497 mL 0.9941 mL 1.2426 mL
100 mM 0.0249 mL 0.1243 mL 0.2485 mL 0.497 mL 0.6213 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Icariside F2

A new phenylpropanoid and an alkylglycoside from Piper retrofractum leaves with their antioxidant and alpha-glucosidase inhibitory activity.[Pubmed:25127165]

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4120-4.

Two new compounds, piperoside (1) and isoheptanol 2(S)-O-beta-D-xylopyranosyl (1-->6)-O-beta-D-glucopyranoside (11), along with 10 known compounds 3,4-dihydroxyallylbenzene (2), 1,2-di-O-beta-D-glucopyranosyl-4-allylbenzene (3), tachioside (4), benzyl-O-beta-D-glucopyranoside (5), Icariside F2 (6), dihydrovomifoliol-3'-O-beta-D-glucopyranoside (7), isopropyl O-beta-D-glucopyranoside (8), isopropyl primeveroside (9), n-butyl O-beta-D-glucopyranoside (10), isoheptanol 2(S)-O-beta-D-apiofuranosyl-(1-->6)-O-beta-D-glucopyranoside (12), were isolated from the leaves of Piper retrofractum. Their structures were determined from 1D-NMR, 2D-NMR, and HR-ESI-MS spectral, a modified Mosher's method, and comparisons with previous reports. All of the isolated compounds showed modest alpha-glucosidase inhibitory (4.60+/-1.74% to 11.97+/-3.30%) and antioxidant activities under the tested conditions.

Soluble epoxide hydrolase inhibitory and anti-inflammatory components from the leaves of Eucommia ulmoides Oliver (duzhong).[Pubmed:25679330]

J Agric Food Chem. 2015 Mar 4;63(8):2198-205.

Eucommia ulmoides leaves have been used as a functional food and drink in China. The purpose of this study was to identify the bioactive constituents with soluble epoxide hydrolase (sEH) inhibitory activity and anti-inflammatory properties. Twenty-seven known compounds (1-27) were isolated from the leaves of E. ulmoides Oliver, and their structures were identified by NMR and ESIMS analysis; three of these, 2,5-dimethoxy-3-glucopyranosyl cinnamic alcohol (11), foliasalacioside E2 (26), and Icariside F2 (27), were obtained from this plant for the first time. Compounds 1-7 exhibited soluble epoxide hydrolase (sEH) inhibitory activity at 100 muM; among them, quercetin (1) and kaempferol (5) displayed potential activities with IC50 values of 22.5 +/- 0.9 and 31.3 +/- 2.6 muM, respectively, with noncompetitive inhibition mode. Nuclear factor kappa B (NF-kappaB) inhibitory activity of the isolated compounds was evaluated by the NF-kappaB liciferase assay in HepG2 cells. Compounds 1, 9, 20, and 27 displayed potent NF-kappaB inhibitory effects, with IC50 values of 15.14 +/- 2.29, 15.23 +/- 2.34, 16.88 +/- 2.17, and 16.25 +/- 2.19 muM, respectively, whereas other compounds showed weak inhibition of NF-kappaB transcriptional activity ranging from 17.54 to 92.6 muM. A structure-activity relationship of flavonoids 1-9 was also discussed. The results obtained in this work might contribute to the understanding of pharmacological activities of E. ulmoides leaves and further investigation on its potential application values for food and drug.

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