Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCC7818 | GSK 789472 hydrochloride |
| Selective dopamine D3 receptor antagonist and D2 partial agonist (pEC50 values are <5.5 and 8.3 respectively). Selective against the D4 receptor in both agonist and antagonist assays. Brain penetrant. | |
| BCC7824 | CBiPES hydrochloride |
| Selective positive allosteric modulator of the mGlu2 receptor (IC50 = 98.2 nM). Mimics the action of LY 379268; attenuates ketamine-evoked histamine release in vivo. | |
| BCC7825 | trans-Ned 19 |
| Nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM); also inhibits [32P]NAADP binding (IC50 = 0.4 nM). Fluorescently labels NAADP receptors in intact cells. Stereosiomer of cis-Ned 19. | |
| BCC7830 | Latrunculin A |
| Reversible inhibitor of actin assembly; blocks actin adenine nucleotide exchange. Complexes with actin in vitro and interacts with actin monomers only, unlike cytochalasins. Prevents actin repolymerization into filaments and disrupts the actin cytoskeleton. | |
| BCC7834 | AMTB hydrochloride |
| TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in a rat model (pIC50 = 6.23). | |
| BCC7835 | NPEC-caged-noradrenalin |
| Noradrenalin caged with the photosensitive 1-(2-nitrophenyl)ethoxycarbonyl (NPEC) group. | |
| BCC7836 | NPEC-caged-serotonin |
| NPEC ((N)-1-(2-nitrophenyl)ethyl) caged version of serotonin. | |
| BCC7837 | NPEC-caged-dopamine |
| NPEC ((N)-1-(2-nitrophenyl)ethyl) caged version of dopamine; releases dopamine leading to D1 receptor activation upon UV light illumination (360 nm). Induces PKA activation and c-Fos expression in cortical and striatal neurons, with striatal neurons demonstrating a significantly greater detection and sensitivity to sub-second dopamine signals as compared to cortical neurons. | |
