Home >> Research Area >>Natural Products>>Flavonoids>> Alpha-Toxicarol

Alpha-Toxicarol

CAS# 82-09-7

Alpha-Toxicarol

Catalog No. BCN6467----Order now to get a substantial discount!

Product Name & Size Price Stock
Alpha-Toxicarol: 5mg $690 In Stock
Alpha-Toxicarol: 10mg Please Inquire In Stock
Alpha-Toxicarol: 20mg Please Inquire Please Inquire
Alpha-Toxicarol: 50mg Please Inquire Please Inquire
Alpha-Toxicarol: 100mg Please Inquire Please Inquire
Alpha-Toxicarol: 200mg Please Inquire Please Inquire
Alpha-Toxicarol: 500mg Please Inquire Please Inquire
Alpha-Toxicarol: 1000mg Please Inquire Please Inquire

Quality Control of Alpha-Toxicarol

Number of papers citing our products

Chemical structure

Alpha-Toxicarol

3D structure

Chemical Properties of Alpha-Toxicarol

Cas No. 82-09-7 SDF Download SDF
PubChem ID 442826 Appearance Powder
Formula C23H22O7 M.Wt 410.4
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1(C=CC2=C3C(=C(C=C2O1)O)C(=O)C4C(O3)COC5=CC(=C(C=C45)OC)OC)C
Standard InChIKey JLTNCZQNGBLBGO-MOPGFXCFSA-N
Standard InChI InChI=1S/C23H22O7/c1-23(2)6-5-11-15(30-23)8-13(24)20-21(25)19-12-7-16(26-3)17(27-4)9-14(12)28-10-18(19)29-22(11)20/h5-9,18-19,24H,10H2,1-4H3/t18-,19+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Alpha-Toxicarol

The herbs of Derris trifoliata Lour.

Biological Activity of Alpha-Toxicarol

Description 1. Alpha-Toxicarol exhibits a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.

Alpha-Toxicarol Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Alpha-Toxicarol Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Alpha-Toxicarol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4366 mL 12.1832 mL 24.3665 mL 48.7329 mL 60.9162 mL
5 mM 0.4873 mL 2.4366 mL 4.8733 mL 9.7466 mL 12.1832 mL
10 mM 0.2437 mL 1.2183 mL 2.4366 mL 4.8733 mL 6.0916 mL
50 mM 0.0487 mL 0.2437 mL 0.4873 mL 0.9747 mL 1.2183 mL
100 mM 0.0244 mL 0.1218 mL 0.2437 mL 0.4873 mL 0.6092 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Alpha-Toxicarol

Highly variable insect control efficacy of Tephrosia vogelii chemotypes.[Pubmed:22970736]

J Agric Food Chem. 2012 Oct 10;60(40):10055-63.

Tephrosia vogelii has been used for generations as a pest control material in Africa. Recently, two chemotypes have been reported based on the occurrence (chemotype 1) or absence (chemotype 2) of rotenoids. This could have an impact on the efficacy and reliability of this material for pest control. We report that chemotype 2 has no pesticidal activity against Callosobruchus maculatus Fabricius (family Chrysomelidae) and that this is associated with the absence of rotenoids. We present a first report of the comparative biological activity of deguelin, tephrosin, Alpha-Toxicarol, and sarcolobine and show that not all rotenoids are equally effective. Tephrosin was less toxic than deguelin which was less active than rotenone, while obovatin 5-methyl ether, the major flavonoid in chemotype 2 was inactive. We also report that in chemotype 1 the occurrence of rotenoids shows substantial seasonal variation.

Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria.[Pubmed:14510590]

J Nat Prod. 2003 Sep;66(9):1166-70.

A new butenylflavanone, (2S)-5-hydroxy-7-methoxy-8-[(E)-3-oxo-1-butenyl]flavanone (1), and a new rotenoid, 4',5'-dihydro-11,5'-dihydroxy-4'-methoxytephrosin (2), as well as three active flavonoids of previously known structure, isoliquiritigenin (3), genistein (4), and chrysoeriol (5), along with nine known inactive compounds, Alpha-Toxicarol (6), sumatrol, 6a,12a-dehydro-Alpha-Toxicarol, 11-hydroxytephrosin, obovatin, marmesin, lupenone, benzyl benzoate, and benzyl trans-cinnamate, were isolated from an ethyl acetate-soluble extract of the stems of Tephrosia toxicaria, using a bioassay based on the induction of quinone reductase (QR) in cultured Hepa 1c1c7 mouse hepatoma cells to monitor chromatographic fractionation. The structures of compounds 1 and 2 were elucidated by spectroscopic data interpretation. All isolates were evaluated for their potential cancer chemopreventive properties utilizing an in vitro assay to determine quinone reductase induction. Selected compounds were tested in a mouse mammary organ culture assay to evaluate the inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced preneoplastic lesions.

Cancer chemopreventive activity of rotenoids from Derris trifoliata.[Pubmed:15229812]

Planta Med. 2004 Jun;70(6):585-8.

A study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) led to the isolation and identification of one new rotenoid, 6aalpha,12aalpha-12a-hydroxyelliptone ( 3), together with five other known rotenoids. In a search for novel cancer chemopreventive agents (anti-tumor promoters), we carried out a primary screening of five of the rotenoids isolated from the plant for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12- O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. The inhibitory activity of 3 was found to be equivalent to that of beta-carotene without any cytotoxicity. Deguelin ( 4) and Alpha-Toxicarol ( 5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. This investigation indicated that rotenoids might be valuable anti-tumor promoters.

Keywords:

Alpha-Toxicarol,82-09-7,Natural Products, buy Alpha-Toxicarol , Alpha-Toxicarol supplier , purchase Alpha-Toxicarol , Alpha-Toxicarol cost , Alpha-Toxicarol manufacturer , order Alpha-Toxicarol , high purity Alpha-Toxicarol

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: