Daurichromenic acidCAS# 82003-90-5 |
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| Cas No. | 82003-90-5 | SDF | Download SDF |
| PubChem ID | 6475854 | Appearance | Powder |
| Formula | C23H30O4 | M.Wt | 370.5 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2S)-2-[(3E)-4,8-dimethylnona-3,7-dienyl]-5-hydroxy-2,7-dimethylchromene-6-carboxylic acid | ||
| SMILES | CC1=CC2=C(C=CC(O2)(C)CCC=C(C)CCC=C(C)C)C(=C1C(=O)O)O | ||
| Standard InChIKey | UYLFTJMQPWWDCW-MVLVPLOLSA-N | ||
| Standard InChI | InChI=1S/C23H30O4/c1-15(2)8-6-9-16(3)10-7-12-23(5)13-11-18-19(27-23)14-17(4)20(21(18)24)22(25)26/h8,10-11,13-14,24H,6-7,9,12H2,1-5H3,(H,25,26)/b16-10+/t23-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Rhododendron dauricum
| Description | 1. Daurichromenic acid is a terpenophenol with a potent anti-HIV activity. |
| Targets | HIV |
Daurichromenic acid Dilution Calculator
Daurichromenic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.6991 mL | 13.4953 mL | 26.9906 mL | 53.9811 mL | 67.4764 mL |
| 5 mM | 0.5398 mL | 2.6991 mL | 5.3981 mL | 10.7962 mL | 13.4953 mL |
| 10 mM | 0.2699 mL | 1.3495 mL | 2.6991 mL | 5.3981 mL | 6.7476 mL |
| 50 mM | 0.054 mL | 0.2699 mL | 0.5398 mL | 1.0796 mL | 1.3495 mL |
| 100 mM | 0.027 mL | 0.135 mL | 0.2699 mL | 0.5398 mL | 0.6748 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Total synthesis of the highly potent anti-HIV natural product daurichromenic acid along with its two chromane derivatives, rhododaurichromanic acids A and B.[Pubmed:14602030]
Org Lett. 2003 Nov 13;5(23):4481-4.
[reaction: see text] The highly potent anti-HIV natural product Daurichromenic acid was successfully synthesized in only five steps with 49% overall yield. The key step in the synthetic strategy involves a microwave-assisted tandem condensation and intramolecular S(N)2'-type cyclization to form the 2H-benzopyran core structure.
Daurichromenic acid-producing oxidocyclase in the young leaves of Rhododendron dauricum.[Pubmed:25918805]
Nat Prod Commun. 2014 Sep;9(9):1329-32.
Rhododendron dauricum L., a flowering tree popular in Hokkaido, produces Daurichromenic acid (DCA), a terpenophenol with a potent anti-HIV activity. The DCA-producing enzyme, named DCA synthase, could be detected in the soluble protein fraction prepared from the young leaves of R. dauricum. DCA synthase catalyzed oxidocyclization of the farnesyl group of grifolic acid to form (+)-DCA as the major reaction product. The DCA synthase reaction proceeds without the need for any cofactors and coenzymes except for molecular oxygen. Interestingly, these catalytic properties of DCA synthase are quite similar to those reported for cannabinoid synthases in the marijuana plant Cannabis sativa L.
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