NSC 33994Selective JAK2 inhibitor CAS# 82058-16-0 |
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Quality Control & MSDS
3D structure
Package In Stock
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| Cas No. | 82058-16-0 | SDF | Download SDF |
| PubChem ID | 5473838 | Appearance | Powder |
| Formula | C28H42N2O2 | M.Wt | 438.65 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 5 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming | ||
| Chemical Name | 2-(diethylaminomethyl)-4-[(E)-4-[3-(diethylaminomethyl)-4-hydroxyphenyl]hex-3-en-3-yl]phenol | ||
| SMILES | CCC(=C(CC)C1=CC(=C(C=C1)O)CN(CC)CC)C2=CC(=C(C=C2)O)CN(CC)CC | ||
| Standard InChIKey | QFNJFVBKASKGEU-OCEACIFDSA-N | ||
| Standard InChI | InChI=1S/C28H42N2O2/c1-7-25(21-13-15-27(31)23(17-21)19-29(9-3)10-4)26(8-2)22-14-16-28(32)24(18-22)20-30(11-5)12-6/h13-18,31-32H,7-12,19-20H2,1-6H3/b26-25+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Selective inhibitor of JAK2 (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM. |
NSC 33994 Dilution Calculator
NSC 33994 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2797 mL | 11.3986 mL | 22.7972 mL | 45.5944 mL | 56.993 mL |
| 5 mM | 0.4559 mL | 2.2797 mL | 4.5594 mL | 9.1189 mL | 11.3986 mL |
| 10 mM | 0.228 mL | 1.1399 mL | 2.2797 mL | 4.5594 mL | 5.6993 mL |
| 50 mM | 0.0456 mL | 0.228 mL | 0.4559 mL | 0.9119 mL | 1.1399 mL |
| 100 mM | 0.0228 mL | 0.114 mL | 0.228 mL | 0.4559 mL | 0.5699 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Selective inhibitor of JAK2 (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.
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Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening.[Pubmed:19447617]
Bioorg Med Chem Lett. 2009 Jul 1;19(13):3598-601.
Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematologic malignancies. A somatic mutation of JAK2 (Val617Phe) was previously shown to occur in 98% of patients with polycythemia vera and 50% of patients with essential thrombocythemia and primary myelofibrosis. Thus, effective JAK2 kinase inhibitors may be of significant therapeutic importance. Here, we applied a structure-based virtual screen to identify novel JAK2 inhibitors. One JAK2 inhibitor in particular, G6, demonstrated remarkable potency as well as specificity, which makes it as a potential lead candidate against diseases related to elevated JAK2 tyrosine kinase activity.
JAK2 inhibitor
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