JAK
Janus kinases (JAKs), belonging to a distinct family of tyrosine kinases, are non-receptor tyrosine kinases that transduce signals of cytokine receptors via diverse signal transduction pathways. Mammalian JAK family consists of four structurally similar members, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2), which are characterized by containing seven JAK homology (JH) domains. The presence of JH1 and JH2 domains is the most intriguing feature of JAK proteins. JH1 domain is the main catalytic domain; while JH2 is usually considered as a catalytically inactive pseudokinase domain. However, results of recent studies have shown that JH2 acts as a dual-specificity protein kinase to phosphorylate two regulatory sites (Ser523 and Tyr570) in JAK2.
Products for JAK
- Cat.No. Product Name Information
- BCC1276 Ruxolitinib (INCB018424)JAK inhibitor
- BCC1400 Bardoxolone methylIKK inhibitor, potent antioxidant inflammation modulator
- BCC1401 Baricitinib phosphateJAK1/JAK2 inhibitor
- BCC1506 CYT387 sulfate saltJAK1/JAK2 inhibitor
- BCC1667 JAK2 Inhibitor V, Z3Jak2 tyrosine kinase inhibitor
- BCC1668 JANEX-1JAK3 inhibitor
- BCC1815 NVP-BSK805ATP-competitive JAK2 inhibitor
- BCC1874 Pyridone 6Pan-JAK inhibitor
- BCC1912 Ruxolitinib phosphateJAK1/JAK2 inhibitor
- BCC1913 Ruxolitinib sulfateJAK inhibitor
- BCC1925 SB1317CDK,JAK and FLT inhibitor
- BCC2056 WHI-P97Janus kinase (JAK)-3 inhibitor
- BCC2057 XL019JAK2 inhibitor,potent and selective
- BCC2189 Tofacitinib (CP-690550) CitratePotent JAK inhibitor
- BCC2190 TG101348 (SAR302503)JAK-2 inhibitor,potent and selective
- BCC2191 AZD1480Potent and selective JAK2 inhibitor; antiangiogenic
- BCC2192 Tofacitinib (CP-690550,Tasocitinib)Janus kinase inhibitor
- BCC2195 Baricitinib (LY3009104, INCB028050)JAK1/JAK2 inhibitor,selective orally bioavailable
- BCC2196 CYT387JAK-1/-2 inhibitor,ATP competitive
- BCC2197 AZ 960JAKs inhibitor
- BCC2199 CEP-33779JAK2 inhibitor,highly selective
- BCC2200 LY2784544JAK2 inhibitor,highly potent and selective
- BCC2201 S-Ruxolitinib (INCB018424)JAK1/2 inhibitor,potent and selective
- BCC2437 1,2,3,4,5,6-HexabromocyclohexaneInhibits JAK2 autophosphorylation
- BCC2438 CercosporamidePotent Mnk2 inhibitor; also inhibits JAK3
- BCC2440 LestaurtinibJAK2/FLT3/TrkA inhibitor
- BCC2441 NSC 33994JAK2 inhibitor
- BCC2442 SD 1008JAK2/STAT3 signaling pathway inhibitor
- BCC2443 TCS 21311JAK3 inhibitor
- BCC2444 ZM 449829Potent, selective JAK3 inhibitor
- BCC4145 GLPG0634JAK1 inhibitor
- BCC6456 Decernotinib(VX-509)Selective and orally active JAK3 inhibitor
- BCC6503 Peficitinb (ASP015K, JNJ-54781532)JAK inhibitor
- BCC8068 Cerdulatinib (PRT062070)Syk/JAK inhibitor