JAK

Janus kinases (JAKs), belonging to a distinct family of tyrosine kinases, are non-receptor tyrosine kinases that transduce signals of cytokine receptors via diverse signal transduction pathways. Mammalian JAK family consists of four structurally similar members, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2), which are characterized by containing seven JAK homology (JH) domains. The presence of JH1 and JH2 domains is the most intriguing feature of JAK proteins. JH1 domain is the main catalytic domain; while JH2 is usually considered as a catalytically inactive pseudokinase domain. However, results of recent studies have shown that JH2 acts as a dual-specificity protein kinase to phosphorylate two regulatory sites (Ser523 and Tyr570) in JAK2.

Products for JAK

  1. Cat.No. Product Name Information
  2. BCC1276 Ruxolitinib (INCB018424)JAK inhibitor
  3. BCC1400 Bardoxolone methylIKK inhibitor, potent antioxidant inflammation modulator
  4. BCC1401 Baricitinib phosphateJAK1/JAK2 inhibitor
  5. BCC1506 CYT387 sulfate saltJAK1/JAK2 inhibitor
  6. BCC1667 JAK2 Inhibitor V, Z3Jak2 tyrosine kinase inhibitor
  7. BCC1668 JANEX-1JAK3 inhibitor
  8. BCC1815 NVP-BSK805ATP-competitive JAK2 inhibitor
  9. BCC1874 Pyridone 6Pan-JAK inhibitor
  10. BCC1912 Ruxolitinib phosphateJAK1/JAK2 inhibitor
  11. BCC1913 Ruxolitinib sulfateJAK inhibitor
  12. BCC1925 SB1317CDK,JAK and FLT inhibitor
  13. BCC2056 WHI-P97Janus kinase (JAK)-3 inhibitor
  14. BCC2057 XL019JAK2 inhibitor,potent and selective
  15. BCC2189 Tofacitinib (CP-690550) CitratePotent JAK inhibitor
  16. BCC2190 TG101348 (SAR302503)JAK-2 inhibitor,potent and selective
  17. BCC2191 AZD1480Potent and selective JAK2 inhibitor; antiangiogenic
  18. BCC2192 Tofacitinib (CP-690550,Tasocitinib)Janus kinase inhibitor
  19. BCC2195 Baricitinib (LY3009104, INCB028050)JAK1/JAK2 inhibitor,selective orally bioavailable
  20. BCC2196 CYT387JAK-1/-2 inhibitor,ATP competitive
  21. BCC2197 AZ 960JAKs inhibitor
  22. BCC2199 CEP-33779JAK2 inhibitor,highly selective
  23. BCC2200 LY2784544JAK2 inhibitor,highly potent and selective
  24. BCC2201 S-Ruxolitinib (INCB018424)JAK1/2 inhibitor,potent and selective
  25. BCC2437 1,2,3,4,5,6-HexabromocyclohexaneInhibits JAK2 autophosphorylation
  26. BCC2438 CercosporamidePotent Mnk2 inhibitor; also inhibits JAK3
  27. BCC2440 LestaurtinibJAK2/FLT3/TrkA inhibitor
  28. BCC2441 NSC 33994JAK2 inhibitor
  29. BCC2442 SD 1008JAK2/STAT3 signaling pathway inhibitor
  30. BCC2443 TCS 21311JAK3 inhibitor
  31. BCC2444 ZM 449829Potent, selective JAK3 inhibitor
  32. BCC4145 GLPG0634JAK1 inhibitor
  33. BCC6456 Decernotinib(VX-509)Selective and orally active JAK3 inhibitor
  34. BCC6503 Peficitinb (ASP015K, JNJ-54781532)JAK inhibitor
  35. BCC8068 Cerdulatinib (PRT062070)Syk/JAK inhibitor

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