S-Ruxolitinib (INCB018424)JAK1/2 inhibitor,potent and selective CAS# 941685-37-6 |
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Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 941685-37-6 | SDF | Download SDF |
| PubChem ID | 50878566 | Appearance | Powder |
| Formula | C17H18N6 | M.Wt | 306.37 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | S-Ruxolitinib; INCB18424 | ||
| Solubility | DMSO : ≥ 100 mg/mL (326.40 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | (3S)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile | ||
| SMILES | C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3 | ||
| Standard InChIKey | HFNKQEVNSGCOJV-HNNXBMFYSA-N | ||
| Standard InChI | InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | S-Ruxolitinib is the chirality of INCB018424. | |||||
| Targets | JAK1 | JAK2 | JAK3 | |||
| IC50 | 3.3 nM | 2.8 nM | 428 nM | |||
S-Ruxolitinib (INCB018424) Dilution Calculator
S-Ruxolitinib (INCB018424) Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.264 mL | 16.3201 mL | 32.6403 mL | 65.2805 mL | 81.6007 mL |
| 5 mM | 0.6528 mL | 3.264 mL | 6.5281 mL | 13.0561 mL | 16.3201 mL |
| 10 mM | 0.3264 mL | 1.632 mL | 3.264 mL | 6.5281 mL | 8.1601 mL |
| 50 mM | 0.0653 mL | 0.3264 mL | 0.6528 mL | 1.3056 mL | 1.632 mL |
| 100 mM | 0.0326 mL | 0.1632 mL | 0.3264 mL | 0.6528 mL | 0.816 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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S-Ruxolitinib is the chirality of INCB018424, is a potent and selective small-molecule Janus kinase 1 (JAK1) and JAK2 inhibitor. It was initially developed to target the constitutive activation of the JAK-STAT pathway. Janus kinases (JAKs) are a family of cytoplasmic tyrosine kinases that mediates signals from the receptors for various cytokines and growth factors that have a key role in haematopoiesis and immune function. Ruxolitinib maintains its anti-JAK activity by competitive inhibition of the ATP-binding catalytic site of the kinase domain. Ruxolitinib is well absorbed at >95%. Exposure of JAK2V617F-positive Ba/F3 cells to ruxolitinib iss shown to result in reduced cellular proliferation.
References
Ruben A. Mesa, Uma Yasothan, Peter Kirkpatrick. Ruxolitinib. Nature Reviews Drug Discovery. 2012; 11: 103-104
John Mascarenhas, Ronald Hoffman. Ruxolitinib: The First FDA Approved Therapy for the Treatment of Myelofibrosis. Clinical Cancer Research. 2012; 18(11): 3008 - 3014
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Ruxolitinib S enantiomer is the S-enantiomer of Ruxolitinib. Ruxolitinib S enantiomer is a JAK inhibitor
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