JAK2 Inhibitor V, Z3Jak2 tyrosine kinase inhibitor CAS# 195371-52-9 |
Related Products
- CYT387 sulfate salt
Catalog No.:BCC1506
CAS No.:1056636-06-6
- Baricitinib phosphate
Catalog No.:BCC1401
CAS No.:1187595-84-1
- JANEX-1
Catalog No.:BCC1668
CAS No.:202475-60-3
- Bardoxolone methyl
Catalog No.:BCC1400
CAS No.:218600-53-4
- Ruxolitinib (INCB018424)
Catalog No.:BCC1276
CAS No.:941678-49-5
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 195371-52-9 | SDF | Download SDF |
| PubChem ID | 238484 | Appearance | Powder |
| Formula | C23H24N2O | M.Wt | 344.45 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | Z3 | ||
| Solubility | DMSO : ≥ 100 mg/mL (290.32 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | 2-methyl-1-phenyl-4-pyridin-2-yl-2-(2-pyridin-2-ylethyl)butan-1-one | ||
| SMILES | CC(CCC1=CC=CC=N1)(CCC2=CC=CC=N2)C(=O)C3=CC=CC=C3 | ||
| Standard InChIKey | SETYDCSRABYHSW-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C23H24N2O/c1-23(15-13-20-11-5-7-17-24-20,16-14-21-12-6-8-18-25-21)22(26)19-9-3-2-4-10-19/h2-12,17-18H,13-16H2,1H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | NSC 42834(JAK2 Inhibitor V, Z3), a novel specific inhibitor of Jak2, inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity.
IC50 value:
Target: Jak2; Jak2-V617F
Z3 selectively inhibited Jak2 kinase function with no effect on Tyk2 or c-Src kinase function. Z3 significantly inhibited proliferation of the Jak2-V617F-expressing, human erythroleukemia cell line, HEL 92.1.7. The Z3-mediated reduction in cell proliferation correlated with reduced Jak2 and STAT3 tyrosine phosphorylation levels as well as marked cell cycle arrest. Finally, Z3 inhibited the growth of hematopoietic progenitor cells isolated from the bone marrow of an essential thrombocythemia patient harboring the Jak2-V617F mutation and a polycythemia vera patient carrying a Jak2-F537I mutation. References: | |||||
JAK2 Inhibitor V, Z3 Dilution Calculator
JAK2 Inhibitor V, Z3 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9032 mL | 14.5159 mL | 29.0318 mL | 58.0636 mL | 72.5795 mL |
| 5 mM | 0.5806 mL | 2.9032 mL | 5.8064 mL | 11.6127 mL | 14.5159 mL |
| 10 mM | 0.2903 mL | 1.4516 mL | 2.9032 mL | 5.8064 mL | 7.2579 mL |
| 50 mM | 0.0581 mL | 0.2903 mL | 0.5806 mL | 1.1613 mL | 1.4516 mL |
| 100 mM | 0.029 mL | 0.1452 mL | 0.2903 mL | 0.5806 mL | 0.7258 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Z3 is a novel specific inhibitor of Jak2 tyrosine kinase. Z3 inhibited Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity.
Featured Products
- Alphitolic acid
Catalog No.:BCN1189
CAS No.:19533-92-7
- Galantamine hydrobromide
Catalog No.:BCN2869
CAS No.:1953-04-4
- Tiopronin (Thiola)
Catalog No.:BCC3870
CAS No.:1953-02-2
- GLP-2 (rat)
Catalog No.:BCC5892
CAS No.:195262-56-7
- N-(3-Methoxybenzyl)oleamide
Catalog No.:BCC6942
CAS No.:883715-21-7
- 4-DAMP
Catalog No.:BCC6661
CAS No.:1952-15-4
- Dihydrosenkyunolide C
Catalog No.:BCC8942
CAS No.:195142-72-4
- 4-Hydroxycinnamamide
Catalog No.:BCN1188
CAS No.:194940-15-3
- Daphnetin 7-methyl ether
Catalog No.:BCN2734
CAS No.:19492-03-6
- ACPT-I
Catalog No.:BCC5702
CAS No.:194918-76-8
- Ginsenoside Rs3
Catalog No.:BCN3716
CAS No.:194861-70-6
- Jujuboside D
Catalog No.:BCN4951
CAS No.:194851-84-8
New Products
- Bay 11-7821(BAY 11-7082)
Catalog No.:BCC2244
CAS No.:19542-67-7
- Wortmannin
Catalog No.:BCC3874
CAS No.:19545-26-7
- Chiirirhamnin
Catalog No.:BCN3179
CAS No.:195450-50-1
- AP1903
Catalog No.:BCC5361
CAS No.:195514-63-7
- Piromidic Acid
Catalog No.:BCC3840
CAS No.:19562-30-2
- Methyl 4-O-feruloylquinate
Catalog No.:BCC9041
CAS No.:195723-10-5
- 2,16,19-Kauranetriol 2-O-beta-D-allopyranoside
Catalog No.:BCN1510
CAS No.:195723-38-7
- (+-)-Byakangelicin
Catalog No.:BCN5000
CAS No.:19573-01-4
- Atrasentan hydrochloride
Catalog No.:BCC1380
CAS No.:195733-43-8
- 2,6,16-Kauranetriol 2-O-beta-D-allopyranoside
Catalog No.:BCN1509
CAS No.:195735-16-1
- HTMT dimaleate
Catalog No.:BCC6736
CAS No.:195867-54-0
- (R)-Nepicastat HCl
Catalog No.:BCC4315
CAS No.:195881-94-8
NSC 42834 (JAK2 Inhibitor V), a novel specific inhibitor of Jak2, inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity.
JAK2 Inhibitor V, Z3,195371-52-9,Z3,Natural Products,JAK, buy JAK2 Inhibitor V, Z3 , JAK2 Inhibitor V, Z3 supplier , purchase JAK2 Inhibitor V, Z3 , JAK2 Inhibitor V, Z3 cost , JAK2 Inhibitor V, Z3 manufacturer , order JAK2 Inhibitor V, Z3 , high purity JAK2 Inhibitor V, Z3
