(RS)-4-Carboxy-3-hydroxyphenylglycineBroad spectrum EAA ligand CAS# 134052-66-7 |
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Quality Control & MSDS
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| Cas No. | 134052-66-7 | SDF | Download SDF |
| PubChem ID | 1297 | Appearance | Powder |
| Formula | C9H9NO5 | M.Wt | 211.17 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Synonyms | (<em>RS</em>)-4C3HPG | ||
| Solubility | Soluble to 100 mM in 1eq. NaOH | ||
| Chemical Name | 4-[amino(carboxy)methyl]-2-hydroxybenzoic acid | ||
| SMILES | C1=CC(=C(C=C1C(C(=O)O)N)O)C(=O)O | ||
| Standard InChIKey | GXZSAQLJWLCLOX-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Broad spectrum EAA agonist/antagonist. Separate isomer (S)-4-Carboxy-3-hydroxyphenylglycine also available. |
(RS)-4-Carboxy-3-hydroxyphenylglycine Dilution Calculator
(RS)-4-Carboxy-3-hydroxyphenylglycine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.7355 mL | 23.6776 mL | 47.3552 mL | 94.7104 mL | 118.388 mL |
| 5 mM | 0.9471 mL | 4.7355 mL | 9.471 mL | 18.9421 mL | 23.6776 mL |
| 10 mM | 0.4736 mL | 2.3678 mL | 4.7355 mL | 9.471 mL | 11.8388 mL |
| 50 mM | 0.0947 mL | 0.4736 mL | 0.9471 mL | 1.8942 mL | 2.3678 mL |
| 100 mM | 0.0474 mL | 0.2368 mL | 0.4736 mL | 0.9471 mL | 1.1839 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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4C3HPG (RS-4-carboxy-3-hydroxyphenylglycine), a weak agonist at metabotropic glutamate receptors, occludes the action of trans-ACPD in hippocampus.[Pubmed:1385184]
Eur J Pharmacol. 1992 Oct 20;221(2-3):401-2.
The determination of the physiological role of glutamatergic metabotropic actions has been hampered by the lack of potent and specific antagonists. It has recently been reported that 4C3HPG (RS-4-carboxy-3-hydroxyphenylglycine) can antagonize metabotropic responses in the central nervous system. The effects of 4C3HPG on metabotropic responses evoked by trans-ACPD were investigated in CA3 pyramidal cells in hippocampal slice cultures. Our results show that in hippocampus 4C3HPG fails to antagonize responses mediated by metabotropic glutamate receptors.
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