Home >> Research Area >>Natural Products>>Flavonoids>> 5,6,7,3',4'-Pentamethoxyflavanone

5,6,7,3',4'-Pentamethoxyflavanone

CAS# 104193-93-3

5,6,7,3',4'-Pentamethoxyflavanone

Catalog No. BCN0753----Order now to get a substantial discount!

Product Name & Size Price Stock
5,6,7,3',4'-Pentamethoxyflavanone: 5mg $357 In Stock
5,6,7,3',4'-Pentamethoxyflavanone: 10mg Please Inquire In Stock
5,6,7,3',4'-Pentamethoxyflavanone: 20mg Please Inquire Please Inquire
5,6,7,3',4'-Pentamethoxyflavanone: 50mg Please Inquire Please Inquire
5,6,7,3',4'-Pentamethoxyflavanone: 100mg Please Inquire Please Inquire
5,6,7,3',4'-Pentamethoxyflavanone: 200mg Please Inquire Please Inquire
5,6,7,3',4'-Pentamethoxyflavanone: 500mg Please Inquire Please Inquire
5,6,7,3',4'-Pentamethoxyflavanone: 1000mg Please Inquire Please Inquire

Quality Control of 5,6,7,3',4'-Pentamethoxyflavanone

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Chemical structure

5,6,7,3',4'-Pentamethoxyflavanone

Chemical Properties of 5,6,7,3',4'-Pentamethoxyflavanone

Cas No. 104193-93-3 SDF Download SDF
PubChem ID N/A Appearance Powder
Formula C20H22O7 M.Wt 374.4
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 5,6,7,3',4'-Pentamethoxyflavanone

The herbs of Gardenia sootepensis

5,6,7,3',4'-Pentamethoxyflavanone Dilution Calculator

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5,6,7,3',4'-Pentamethoxyflavanone Molarity Calculator

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Preparing Stock Solutions of 5,6,7,3',4'-Pentamethoxyflavanone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6709 mL 13.3547 mL 26.7094 mL 53.4188 mL 66.7735 mL
5 mM 0.5342 mL 2.6709 mL 5.3419 mL 10.6838 mL 13.3547 mL
10 mM 0.2671 mL 1.3355 mL 2.6709 mL 5.3419 mL 6.6774 mL
50 mM 0.0534 mL 0.2671 mL 0.5342 mL 1.0684 mL 1.3355 mL
100 mM 0.0267 mL 0.1335 mL 0.2671 mL 0.5342 mL 0.6677 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 5,6,7,3',4'-Pentamethoxyflavanone

A stilbene dimer and flavonoids from the aerial parts of Chromolaena odorata with proprotein convertase subtilisin/kexin type 9 expression inhibitory activity.[Pubmed:32335358]

Bioorg Chem. 2020 Jun;99:103869.

Investigation of components of the chloroform-soluble and ethyl acetate-soluble extracts of the aerial parts of Chromolaena odorata L. selected by PCSK9 mRNA expression monitoring assay in HepG2 cells led to the isolation of a new stilbene dimer, (+)-8b-epi-ampelopsin A (1), and 30 known compounds (2-31). The structures of the isolates were established by interpretation of NMR spectroscopic data and the stereochemistry of the new stilbene (1) was proposed based on ECD and NMR calculations. Among the isolates, 1, 5,6,7,4'-tetramethoxyflavanone (6), 5,6,7,3',4'-pentamethoxyflavanone (7), acacetin (18), and uridine (21) were found to inhibit PCSK9 mRNA expression with IC50 values of 20.6, 21.4, 31.7, 15.0, and 13.7 microM, respectively. Furthermore, the most abundant isolate among the selected compounds, 6, suppressed PCSK9 and low-density lipoprotein receptor protein expression in addition to downregulating the mRNA expression of HNF-1alpha.

Polymethoxyflavones in peel of Citrus reticulata 'Chachi' and their biological activities.[Pubmed:28551233]

Food Chem. 2017 Nov 1;234:254-261.

Citrus polymethoxyflavones (PMFs) have been of increasing interest due to their extensive biological activities. In the present study, a total of eight PMFs were isolated from the peel of Citrus reticulata 'Chachi' (CRC). They were individually identified as 5-hydroxy-6,7,8,4'-tetramethoxyflavone (1), 5,6,7,3',4'-pentamethoxyflavanone (2), 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone (3), 3,5,6,7,8,3',4'- heptamethoxyflavone (4), 5,6,7,8,3',4'-hexamethoxyflavone (5), 5,6,7,8,4'-pentamethoxyflavone (6), 6,7,8,3',4'-pentamethoxyflavanone (7) and 5,6,7,3',4'-pentamethoxyflavone (8) by nuclear magnetic resonance and mass spectroscopic analysis. 6,7,8,3',4'-Pentamethoxyflavanone was isolated from the peel of CRC for the first time. The content of PMFs was firstly quantified in both the peel of CRC and PMF-rich extract by HPLC analysis. Furthermore, the biological activities of PMF compounds were investigated. 3,5,6,7,8,3',4'-Heptamethoxyflavone demonstrated potent sterol regulatory element-binding proteins inhibition activity and 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone exhibited strong antiproliferative activity against tumor cell lines. The isolated PMF compounds could also significantly inhibit NO production and the effect varied mainly depending on the number of methoxy groups.

Isolation and identification of two new flavanones and a chalcone from Citrus kinokuni.[Pubmed:11605671]

Chem Pharm Bull (Tokyo). 2001 Oct;49(10):1356-8.

Two new flavanones and one chalcone were isolated from the peel of Citrus kinokuni Hort. ex Tanaka and identified as (2S)-5,6,7,8,4'-pentamethoxyflavanone (1), (2S)-5,6,7,3',4'-pentamethoxyflavanone (2) and 2'-hydroxy-3,4,3',4',6'-pentamethoxychalcone (3). The structures of new compounds were elucidated by spectroscopic analysis.

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