6-HydroxycoumarinCAS# 6093-68-1 |
Quality Control & MSDS
3D structure
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| Cas No. | 6093-68-1 | SDF | Download SDF |
| PubChem ID | 99477 | Appearance | Powder |
| Formula | C9H6O3 | M.Wt | 162 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 6-hydroxychromen-2-one | ||
| SMILES | C1=CC2=C(C=CC(=O)O2)C=C1O | ||
| Standard InChIKey | CJIJXIFQYOPWTF-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C9H6O3/c10-7-2-3-8-6(5-7)1-4-9(11)12-8/h1-5,10H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
6-Hydroxycoumarin Dilution Calculator
6-Hydroxycoumarin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 6.1728 mL | 30.8642 mL | 61.7284 mL | 123.4568 mL | 154.321 mL |
| 5 mM | 1.2346 mL | 6.1728 mL | 12.3457 mL | 24.6914 mL | 30.8642 mL |
| 10 mM | 0.6173 mL | 3.0864 mL | 6.1728 mL | 12.3457 mL | 15.4321 mL |
| 50 mM | 0.1235 mL | 0.6173 mL | 1.2346 mL | 2.4691 mL | 3.0864 mL |
| 100 mM | 0.0617 mL | 0.3086 mL | 0.6173 mL | 1.2346 mL | 1.5432 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Coumarins incorporating hydroxy- and chloro-moieties selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II.[Pubmed:20580555]
Bioorg Med Chem Lett. 2010 Aug 1;20(15):4511-4.
A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties in positions 3-, 4-, 6- and 7- of the heterocyclic ring were investigated for the inhibition of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1). These coumarins were very weak or ineffective as inhibitors of the house-keeping, offtarget isoforms CA I and II, but showed effective, submicromolar inhibition of the transmembrane, tumor-associated isoforms CA IX and XII. The nature and position of the groups substituting the coumarin ring greatly influenced CA inhibitory properties. 6-Hydroxycoumarin showed K(I)s >100 microM against CA I and II, of 0.198 microM against CA IX and of 0.683 microM against CA XII, being thus a selective, efficient inhibitor for the tumor-associated over cytosolic isoforms. These compounds are also excellent leads for designing isoform-selective enzyme inhibitors.
6-Hydroxycoumarin is a coumarin which has anti-inflammatory, anti-pyretic, anti-oxidant, vasodilator, anti-amoebic, anti-bacterial, anti-fungal, bacteriostatic and antitumor activity.
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