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7-Methoxy-beta-carboline-1-propionic acid

CAS# 137756-13-9

7-Methoxy-beta-carboline-1-propionic acid

Catalog No. BCN2995----Order now to get a substantial discount!

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Quality Control of 7-Methoxy-beta-carboline-1-propionic acid

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Chemical structure

7-Methoxy-beta-carboline-1-propionic acid

3D structure

Chemical Properties of 7-Methoxy-beta-carboline-1-propionic acid

Cas No. 137756-13-9 SDF Download SDF
PubChem ID 12082492 Appearance Powder
Formula C15H14N2O3 M.Wt 270.3
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-(7-methoxy-9H-pyrido[3,4-b]indol-1-yl)propanoic acid
SMILES COC1=CC2=C(C=C1)C3=C(N2)C(=NC=C3)CCC(=O)O
Standard InChIKey WEBVBZDGWMAXEF-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 7-Methoxy-beta-carboline-1-propionic acid

The herbs of Eurycoma longifolia

Biological Activity of 7-Methoxy-beta-carboline-1-propionic acid

Description1. 7-Methoxy-beta-carboline-1-propionic acid demonstrates significant antimalarial activity as judged by studies conducted with cultured Plasmodium falciparum strains.
TargetsAntifection

7-Methoxy-beta-carboline-1-propionic acid Dilution Calculator

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7-Methoxy-beta-carboline-1-propionic acid Molarity Calculator

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Preparing Stock Solutions of 7-Methoxy-beta-carboline-1-propionic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.6996 mL 18.498 mL 36.9959 mL 73.9919 mL 92.4898 mL
5 mM 0.7399 mL 3.6996 mL 7.3992 mL 14.7984 mL 18.498 mL
10 mM 0.37 mL 1.8498 mL 3.6996 mL 7.3992 mL 9.249 mL
50 mM 0.074 mL 0.37 mL 0.7399 mL 1.4798 mL 1.8498 mL
100 mM 0.037 mL 0.185 mL 0.37 mL 0.7399 mL 0.9249 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 7-Methoxy-beta-carboline-1-propionic acid

Cytotoxic and antimalarial constituents of the roots of Eurycoma longifolia.[Pubmed:1800638]

J Nat Prod. 1991 Sep-Oct;54(5):1360-7.

By bioactivity-directed fractionation, five cytotoxic constituents have been characterized from the roots of Eurycoma longifolia collected in Kalimantan, Indonesia. Four canthin-6-one alkaloids, namely, 9-methoxycanthin-6-one, 9-methoxycanthin-6-one-N-oxide, 9-hydroxycanthin-6-one, and 9-hydroxycanthin-6-one-N-oxide, and one quassinoid, eurycomanone, were found to be cytotoxic principles. Each of these compounds was evaluated against a panel of cell lines comprising a number of human cancer cell types [breast, colon, fibrosarcoma, lung, melanoma, KB, and KB-V1 (a multi-drug resistant cell line derived from KB)] and murine lymphocytic leukemia (P-388). The canthin-6-ones 1-4 were found to be active with all cell lines tested except for the KB-V1 cell line. Eurycomanone was inactive against murine lymphocytic leukemia (P-388) but was significantly active against the human cell lines tested. Two additional isolates, the beta-carboline alkaloids beta-carboline-1-propionic acid and 7-Methoxy-beta-carboline-1-propionic acid, were not significantly active with these cultured cells. However, compounds 5 and 7 were found to demonstrate significant antimalarial activity as judged by studies conducted with cultured Plasmodium falciparum strains. The structures of the novel compounds 2-4 and 7 were established by spectral and chemical methods.

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