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8-Acetyl-7-hydroxycoumarin

CAS# 6748-68-1

8-Acetyl-7-hydroxycoumarin

Catalog No. BCN0036----Order now to get a substantial discount!

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Quality Control of 8-Acetyl-7-hydroxycoumarin

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Chemical structure

8-Acetyl-7-hydroxycoumarin

3D structure

Chemical Properties of 8-Acetyl-7-hydroxycoumarin

Cas No. 6748-68-1 SDF Download SDF
PubChem ID 5411574 Appearance Powder
Formula C11H8O4 M.Wt 204.2
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 8-acetyl-7-hydroxychromen-2-one
SMILES CC(=O)C1=C(C=CC2=C1OC(=O)C=C2)O
Standard InChIKey XWYMACPLPPQCHC-UHFFFAOYSA-N
Standard InChI InChI=1S/C11H8O4/c1-6(12)10-8(13)4-2-7-3-5-9(14)15-11(7)10/h2-5,13H,1H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 8-Acetyl-7-hydroxycoumarin

The herbs of Murraya paniculata

Biological Activity of 8-Acetyl-7-hydroxycoumarin

Description8-Acetyl-7-hydroxycoumarin shows an interesting activity against V. cholerae, a key bacterium in the contaminated water.

8-Acetyl-7-hydroxycoumarin Dilution Calculator

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8-Acetyl-7-hydroxycoumarin Molarity Calculator

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Preparing Stock Solutions of 8-Acetyl-7-hydroxycoumarin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.8972 mL 24.4858 mL 48.9716 mL 97.9432 mL 122.429 mL
5 mM 0.9794 mL 4.8972 mL 9.7943 mL 19.5886 mL 24.4858 mL
10 mM 0.4897 mL 2.4486 mL 4.8972 mL 9.7943 mL 12.2429 mL
50 mM 0.0979 mL 0.4897 mL 0.9794 mL 1.9589 mL 2.4486 mL
100 mM 0.049 mL 0.2449 mL 0.4897 mL 0.9794 mL 1.2243 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 8-Acetyl-7-hydroxycoumarin

Probing the binding of 8-Acetyl-7-hydroxycoumarin to human serum albumin by spectroscopic methods and molecular modeling.[Pubmed:19243988]

Spectrochim Acta A Mol Biomol Spectrosc. 2009 Jul;73(1):35-40.

Interaction of 8-Acetyl-7-hydroxycoumarin with human serum albumin (HSA) at pH 7.40 has been investigated at 291, 301 and 310 K, respectively, employing the steady fluorescence, circular dichroism (CD) and molecular modeling methods. The quenching mechanism and binding constants were determined by the fluorescence quenching experiments. Thermodynamic data showed that 8-Acetyl-7-hydroxycoumarin was included in the hydrophobic cavity of HSA via hydrophobic interactions. The result of CD indicated that the binding of 8-Acetyl-7-hydroxycoumarin to HSA causes a slight conformational change of the protein. Furthermore, upon binding with HSA, the fluorescence spectra of the 8-Acetyl-7-hydroxycoumarin exhibits appreciable hypsochromic shift associated with an enhancement in the fluorescence intensity. The binding constant (K) and the standard free energy change (DeltaG0) have been also calculated according to the fluorescence data of the ligand, which is in good agreement with the values determined by fluorescence quenching data of HSA. Computational mapping of the possible binding sites of 8-Acetyl-7-hydroxycoumarin revealed that the molecule was bound in the large hydrophobic cavity of subdomain IIA mainly by the hydrophobic interaction and also by the hydrogen bonding interactions between 8-Acetyl-7-hydroxycoumarin and the residues His 242, Arg 222, and Arg 218.

Antifungal and antibacterial activities of Mexican tarragon (Tagetes lucida).[Pubmed:19127719]

J Agric Food Chem. 2006 May 17;54(10):3521-7.

Mexican tarragon (Tagetes lucida Cv. Asteraceae: Campanulatae) is an important, nutritious plant and an effective herbal medicine. Seven coumarins, 7,8-dihydroxycoumarin (4), umbelliferone (7-hydroxycoumarin) (5), scoparone (6,7-dimethoxycoumarin) (7), esculetin (6,7-dihydroxycoumarin) (11), 6-hydroxy-7-methoxycoumarin (12), herniarin (7-methoxycoumarin) (13), and scopoletin (6-methoxy-7-hydroxycoumarin) (14), and three flavonoids, patuletin (18), quercetin (19), and quercetagetin (20), were isolated from CH2Cl2 and MeOH extracts from aerial parts of T. lucida. In addition, 6,7-diacetoxy coumarin (15), 6-methoxy-7-acetylcoumarin (16), and 6-acetoxy-7-methoxycoumarin (17) derivatives were synthesized. 8-Methoxypsoralen (1), 8-Acetyl-7-hydroxycoumarin (2), 7,8-dihydroxy-6-meth-oxycoumarin (3), 6,7-dimethoxy-4-methylcoumarin (6), 5,7-dihydroxy-4-methylcoumarin (8), 4-hydroxycoumarin (9), 4-hydroxy-6,7-dimethylcoumarin (10), naringenin (21), glycoside-7-rhamnonaringin (22), and rutin (23) were commercially obtained (Sigma-Aldrich). All of these compounds and extracts (M1 and M2) were assayed against bacteria and fungi. The antibacterial activity was determined on Bacillus subtilis, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Salmonella typhi, Salmonella sp., Shigella boydii, Shigella sp., Enterobacter aerogenes, Enterobacter agglomerans, Sarcina lutea, Staphylococcus epidermidis, Staphylococcus aureus, Yersinia enterolitica, Vibrio cholerae (three El Tor strains, CDC-V12, clinic case, and INDRE-206, were obtained from contaminated water), and V. cholerae (NO-O1). The evaluated fungi were Aspergillus niger, Penicillium notatum, Fusarium moniliforme, Fusarium sporotrichum, Rhizoctonia solani, and Trichophyton mentagrophytes. The most active compounds against Gram-positive and -negative bacteria were the dihydroxylated coumarins 3 and 4. In addition, 2-4, 6, 7, and 11 showed an interesting activity against V. cholerae, a key bacterium in the contaminated water; 2-4 were the most active. Coumarins were the most effective compounds against Gram-negative bacteria. The extract MeOH/CH2Cl2 (1: 4) M2 at 0.4 microg/disk inhibited the growth of E. coli and P. mirabilis (40%), K. pneumoniae (31.1%), Salmonella sp. (35.5%), and Shigella sp. (0%) at 72 h of culture. The dimethoxy compounds 6 and 7 showed a strong activity against fungal strains, especially T. mentagrophytes and R. solani (100% of inhibition at 125.0 and 250.0 microg/mL, respectively).

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